Distribution of <i>FCN2</i> genotypes and alleles among visceral leishmaniasis cases and healthy controls.

<p>Note: CI, confidence interval; OR, odds ratio; NS, not significant; NA, not applicable. Percentage may not add up to 100 due to rounding errors</p><p>^# Adjusted <i>P</i> values for age, gender and ethnicity</p><p>Distribution of <i>FCN2</i> genotypes and alleles among visceral leishmaniasis cases and healthy controls.</p

Association of functional <i>FCN2</i> haplotypes and visceral leishmaniasis.

<p>Note: CI, confidence interval; OR, odds ratio; NS, not significant; NA, not applicable. Percentage may not add up to 100 due to rounding errors</p><p>^#Adjusted <i>P</i> values for age, gender and ethnicity</p><p>Association of functional <i>FCN2</i> haplotypes and visceral leishmaniasis.</p

Distribution of ficolin-2 serum levels with +6359C>T variant in controls.

<p>Box-plots illustrate medians with 25 and 75 percentiles with whiskers to 10 and 90 percentiles. Ficolin-2 serum levels were measured and separated based on different genotypes of <i>FCN2</i> variant +6359C>T. <i>P =</i> 0.03 illustrated in the figure is calculated by Kruskal-Wallis rank sum test.</p

Geographical location and allele distribution of rs1518111 (2195 A>G, intron), rs1554286 (2607 C>T, intron) and rs3024498 (5311 A>G) polymorphism in tribe and caste population of India.

<p>Population no. 1 to 16 belongs to castes (Fig A, C and E). Population no. 17 to 34 belongs to tribes (Fig B, D and F).</p

Sample size, mean age and sex ratio of case and control samples.

<p>Sample size, mean age and sex ratio of case and control samples.</p

Prevalence (yearly in millions) of different infectious disease (Visceral Leishmaniasis, Leprosy, Tuberculosis Malaria and Filaria) in worldwide and Indian region.

<p>Prevalence (yearly in millions) of different infectious disease (Visceral Leishmaniasis, Leprosy, Tuberculosis Malaria and Filaria) in worldwide and Indian region.</p

A. Distribution of genotype frequencies for<i>IL10</i> polymorphism, rs1518111 A>G; rs1554286 C>T; rs3024496 C>T and rs3024498 A>G in VL case and control subjects

<p>. B. Distribution of allele frequencies for <i>IL10</i> polymorphism, rs1518111 A>G; rs1554286 C>T; rs3024496 C>T and rs3024498 A>G in VL case and control subjects.</p

The structure of the human <i>IL10</i> (chr1, 206945839–206940947; ENST00000423557).

<p>Exons of the gene are shown in pink, introns in brown. rs1518111 (2195 A>G) and rs1554286 (2607 C>T) were the intronic variant of second and third exons while rs3024496 (4976 T>C) and rs3024498 (5311 A>G) were the 3’ UTR variant of fifth exons.</p

Primer sequence, GC % and annealing temperature of <i>IL10</i> exons.

<p>Primer sequence, GC % and annealing temperature of <i>IL10</i> exons.</p

Linkage Disequilibrium (LD) of studied <i>IL-10</i> loci rs1518111 (2195 A>G, intron), rs1554286 (2607 C>T, intron), rs3024496 (4976 T>C, 3’ UTR), rs3024498 (5311 A>G, 3’ UTR) in VL case and control groups.

<p>Linkage Disequilibrium (LD) of studied <i>IL-10</i> loci rs1518111 (2195 A>G, intron), rs1554286 (2607 C>T, intron), rs3024496 (4976 T>C, 3’ UTR), rs3024498 (5311 A>G, 3’ UTR) in VL case and control groups.</p