Measure Data for a General Class of Nonlinear Elliptic Problems

We consider nonlinear elliptic inclusion having a measure in the right-hand side of the type $\beta(u)-div a(x,Du)\ni \mu$ in $\Omega$ a bounded domain in $\mathbb{R}^{N},$ with $\beta$ is a maximal monotone graph in $\mathbb{R}^2$ and $a(x,Du)$ is a Leray-Lions type operator. We study a suitable notion of solution for this kind of problem. The functional setting involves anisotropic Sobolev spaces.Comment: 2

The prognostic significance of ALDH1A1 expression in early invasive breast cancer

Aims: Aldehyde dehydrogenase family 1 member A1 (ALDH1A1)is reportedly a key ALDH isozyme linked to the cancer stem cells (CSC) of many solid tumours, where it is involved in self-renewal, differentiation and self-protection. In this study, the prognostic significance of ALDH1A1 expression in early invasive breast cancer (BC) and its role as a BC stem cell (BCSC) were evaluated.Methods: ALDH1A1 expression was assessed, using immunohistochemistry and tissue microarrays, in a large well- characterised BC cohort. ALDH1A1 mRNA expression was also assessed at the transcriptomic levels, utilising data from the Molecular Taxonomy of Breast Cancer International Consortium. The associations of ALDH1A1 with clinicopathological parameters, other stem cell markers and patient outcomes were determined.Results: ALDH1A1 was expressed in 71% of BC cases, at both the protein and mRNA levels. High ALDH1A1 expression was associated with poor prognostic features, including high grade, poor Nottingham Prognostic Index (NPI), lymph node metastasis and highly proliferative ER+ (luminal B) and triple negative (TNBC) subtypes. ALDH1A1 expression was positively correlated with the expression of CD44, CD24, TWIST, SOX9, EPCAM and CD133. The high immunoexpression of ALDH1A1 was significantly associated with poor BC-specific survival [less than] 0.001), and specifically in the luminal B and TNBC subtypes (P=0.042 and P=0.003, respectively). The immunoexpression of ALDH1A1 was an independent predictor of poor prognosis (P=0.015).Conclusions: ALDH1A1, as assessed using IHC, seems to act as a BCSC marker associated not only with other BCSC markers but also with poor prognostic characteristics and poor outcomes, particularly in the luminal B and TNBC subtypes

استطلاع آراء القطريين والوافدين حول استضافة كأس العالم لكرة القدم 2022

This report presents the results of The Qatar 2022 FIFA World Cup survey of Qatari nationals and white-collar expatriates residing in Qatar. The study was conducted and funded by the Social and Economic Survey Research Institute (SESRI) at Qatar University in collaboration with the University of Florida. The data are intended to inform planners and decision makers, as well as the academic community. All those connected with this project are grateful to the hundreds of Qatari nationals and white-collar residents who gave their valuable time to participate in this survey. The successful completion of the survey was made possible through the contributions of many dedicated individuals who work at the Social and Economic Survey Research Institute (SESRI), Qatar University, and at Department of Tourism, Recreation and Sport Management, College of Health and Human Performance at the University of Florida. The Social & Economic Survey Research Institute (SESRI) is an independent research organization at Qatar University. Since its inception in 2008, it has developed a strong survey-based infrastructure in order to provide high quality survey data for planning and research in the social and economic sectors.الهدف من هذا المشروع هو تقييم مدى تأثير كأس العالم على تغيير نوعية حياة الأشخاص الذين يعيشون في دولة قطر من خلال تقييم تأثير الإعداد لهذا الحدث على البلد والمنطقة. وقد تم الإشارة إلى إرث الفعالية في كلمات رئيس لجنة ملف قطر 2022 ،الشيخ محمد بن حمد آل ثاني: "إن المنافع الاقتصادية ستكون كبيرة لكل بلد في منطقة الشرق الأوسط. وسيكون منصة كبيرة نحو تغيير نظرة العالم الإسلامي ومنطقة الشرق الأوسط للعالم الخارجي". أهداف الدراسة ذات شقين: أ) دراسة تأثيرات الفعالية على الاتجاهات العامة، ونوعية الحياة والتصورات و دعم كأس العالم في دولة قطر وعالقة ذلك مع نوعية حياة المقيمين من أجل تحديد آثار الفعالية على المواطنين و المقيمين في دولة قطر؛ ب) وضع بيانات مرجعية للمواطنين و للمقيمين في دولة قطر بشأن تأثيرات كأس العالم على المنطقة. تتمثل أهمية الدراسة في ثلاث جوانب: أولا توفر بيانات أساسية وتضع أساسا لنهج طولي لتقييم آثار الفعاليات الكبيرة، و هو ما ينقصنا حاليا في أدبيات الاطار النظري. ثانيا اقتراح نموذج لتقييم العوامل التي تؤثر على المواقف تجاه الفعالية، ونوعية الحياة ودعم الفعالية في دولة مثل قطر التي تمثل منطقة الشرق الأوسط والقيم الثقافية والحياتية المرتبطة بالبلد والمنطقة. ثالثا يسمح هذا التقييم بتشكيل وتنفيذ سياسة من شأنها أن تؤدي إلى تدخلات لتحسين نوعية حياة السكان والحصول على تأييدهم تجاه الفعالية من خلال مشاركتهم في عملية استضافة الحدث. بالإضافة إلى ذلك، ستوفر الدراسة لصناعة الرياضة في دولة قطر والمنظمات المرتبطة بكرة القدم، مثل اللجنة العليا للمشاريع والإرث، معلومات تساعد على صياغة استراتيجيات الاتصال ذات الصلة مع وسائل الإعلام وغيرها من الجهات المعنية (مثل، الهيئة العامة للسياحة) و يمكن أن تكون البيانات الأساسية أرضية للدارسين الذين يهدفون إلى مراقبة تصورات مشابهة للعمل/ البحث في المستقبل، و بالتالي إيجاد بصمة في المجال التعليمي. في مسح كأس العالم لكرة القدم 2022 في قطر، تم إجراء مقابلات مع عينة تمثل المواطنين القطريين و الوافدين أصحاب المهن المكتبية. بشكل عام، تم عقد 2163 مقابلة، منها1058))مع المواطنين القطريين و(1105) مع الوافدين من أصحاب المهن المكتبية. تم اختيار المواطنين القطريين و الوافدين أصحاب المهن المكتبية من أسر من جميع البلديات في دولة قطر وتم إجراء مقابلات شخصية باللغة العربية أو الإنجليزية اعتمادا على برنامج استخدام الحاسب. يوجد مزيد من التفاصيل عن منهجية البحث في القسم السابع. ملاحظة: تشير كلمة الوافدون/الوافدين في التقرير إلى أفراد العينة من غير القطريين والذين تم وصفهم في موجز المنهجية بأصحاب المهن المكتبية

Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer

The majority of breast cancers are oestrogen receptor positive (ER+) and are subject to endocrine therapy however, an unpredictable subgroup of patients will develop resistance to endocrine therapy. SLC7A5/SLC3A2 complex is a major route for the transport of large neutral essential amino acids through the plasma membrane. Alterations in the expression and function of those amino acid transporters lead to metabolic reprogramming, which contributing to the tumorigenesis and drug resistance. This study aims to assess the effects and roles of SLC7A5/SLC3A2 co-expression in predicting response to endocrine therapy in patients with ER+ breast cancer. The biological and clinical impact of SLC7A5/SLC3A2 co-expression was assessed in large annotated cohorts of ER+/HER2- breast cancer with long-term follow-up at the mRNA and protein levels. In vitro experiments were conducted to investigate the effect of SLC7A5/SLC3A2 knockdown in the proliferation of cancer cells and to the sensitivity to tamoxifen. We found that proliferation-related genes are highly expressed in subgroup of patients with high SLC7A5/SLC3A2, and knockdown of SLC7A5/SLC3A2 decreased proliferation of ER+ breast cancer cells. In patients treated with endocrine therapy, high SLC7A5/SLC3A2 co-expression was associated with poor patient outcome, and depletion of SLC7A5/SLC3A2 using siRNA increased the sensitivity of breast cancer cells to tamoxifen. On the basis of our findings, SLC7A5/SLC3A2 co-expression has the potential of identifying a subgroup of ER+/HER2- breast cancer patients who fail to benefit from endocrine therapy and could guide the choice of other alternative therapy

Glutamate dehydrogenase (GLUD1) expression in breast cancer

Dysregulated cellular metabolism is regarded as one of the hallmarks of cancer with some tumours utilising the glutamine metabolism pathway for their sustained proliferation and survival. Glutamate dehydrogenase (GLUD1) is a key enzyme in glutaminolysis converting glutamate to α-Ketoglutarate for entry into the TCA cycle. Breast cancer (BC) comprises a heterogeneous group of tumours in terms of molecular biology and clinical behaviour, and we have previously shown that altered glutamine metabolism varies substantially among the different molecular subtypes. We hypothesise that the prognostic value of GLUD1 expression will differ between the BC molecular subtypes and may act as a potential therapeutic target for BC tumours.Methods: GLUD1 was assessed at the DNA, mRNA (n=1,980) and protein (n=1,300) levels in large and well-characterised cohorts and correlated with clinicopathological parameters, molecular subtypes, patient outcome and treatments. Results: There was a correlation between GLUD1 mRNA and GLUD1 protein expression which were highly expressed in low grade Luminal/ER+ BC (

المسح السنوي الشامل : مسح عن الحياة في دولة قطر 2014

This Executive Summary presents the highlights of the 2014 Omnibus survey, the fourth in a series of Omnibus surveys since 2010. The surveys were carried out by the Social and Economic Survey Research Institute (SESRI) of Qatar University. Each Omnibus survey interviews a large and representative sample of Qatari citizens, resident expatriates and laborers. In these surveys, we asked a number of questions covering several topics of importance to Qatari society, including their attitudes and behaviors related to media; political values and attitudes; gender; charities and charitable donations; traffic; and laborers. The survey was designed and carried out in accordance with the highest scientific and ethical standards. Respondents were assured that their answers would be confidential and presented in an aggregate format. This project was fully funded by the Social and Economic Survey Research Institute (SESRI) at Qatar University. The findings made herein are solely the responsibility of the authors.يقدم هذا التقرير الموجز أبرز ما في المسح الشامل لعام 2014 ،الرابع في سلسلة المسوح الشاملة منذ عام 2010 .تم تنفيذ البحوث من قبل معهد البحوث الاجتماعية والاقتصادية المسحية((SESRI بجامعة قطر. في كل مسح شامل تم استطلاع آراء عينة كبيرة تمثل المواطنين القطريين، والمقيمين والعمال. في هذه المسوح تم طرح عدد من الأسئلة تغطي العديد من المواضيع التي تهم المجتمع القطري، بما في ذلك المواقف والسلوكيات المتعلقة بوسائل الإعلام؛ والقيم والمواقف السياسية؛ دور الرجل والمرأة؛ المؤسسات والتبرعات الخيرية؛ وحركة المرور؛ والعمال الوافدين. صمم ونفذ هذا المسح وفقا لأعلى المعايير العلمية والأخلاقية. وتم التأكيد على المشاركين بأن إجابتهم سرية ومقدمة في شكل إجمالي. وقد تم تمويل هذا المشروع بالكامل من قِبل معهد البحوث الاجتماعية والاقتصادية المسحية بجامعة قطر. وإن الاستنتاجات الموجودة في هذا التقرير هي مسؤولية المؤلفين وحدهم

Home cancer care research: a bibliometric and visualization analysis (1990-2021)

Home cancer care research (HCCR) has accelerated, as considerable attention has been placed on reducing cancer-related health costs and enhancing cancer patients' quality of life. Understanding the current status of HCCR can help guide future research and support informed decision-making about new home cancer care (HCC) programs. However, most current studies mainly detail the research status of certain components, while failing to explore the knowledge domain of this research field as a whole, thereby limiting the overall understanding of home cancer care. We carried out bibliometric and visualization analyses of Scopus-indexed papers related to home cancer care published between 1990-2021, and used VOSviewer scientometric software to investigate the status and provide a structural overview of the knowledge domain of HCCR (social, intellectual, and conceptual structures). Our findings demonstrate that over the last three decades, the research on home cancer care has been increasing, with a constantly expanding stream of new papers built on a solid knowledge base and applied to a wide range of research themes

The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer

Background: Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significance of IDH2 at transcriptome and protein expression levels in pre-invasive and invasive disease.Methods: Utlising, tissue microarrays from a large well annotated BC cohort including ductal carcinoma in situ and invasive breast cancer (IBC), IDH2 was assessed at the transcriptomic and proteomic level. The associations between clinicopathological factors including LVI status, prognosis and the expression of IDH2 were evaluated.Results: In pure DCIS and IBC, high IDH2 protein expression was associated with features of aggressiveness including high nuclear grade, larger size, comedo-necrosis and hormonal receptor negativity and LVI, higher grade, larger tumour size, high NPI, HER2 positivity, and hormonal receptor negativity, respectively. High expression of IDH2 either in mRNA or protein levels was associated with poor patient’s outcome in both DCIS and IBC.  Multivariate analysis revealed that IDH2 protein expression was an independent risk factor for shorter BC specific-survival.Conclusion: Further functional studies to decipher the role of IDH2 and its mechanism of action as a driver of BC progression and LVI are warranted

The genetic landscape of autism spectrum disorder in the Middle Eastern population

Introduction: Autism spectrum disorder (ASD) is characterized by aberrations in social interaction and communication associated with repetitive behaviors and interests, with strong clinical heterogeneity. Genetic factors play an important role in ASD, but about 75% of ASD cases have an undetermined genetic risk.Methods: We extensively investigated an ASD cohort made of 102 families from the Middle Eastern population of Qatar. First, we investigated the copy number variations (CNV) contribution using genome-wide SNP arrays. Next, we employed Next Generation Sequencing (NGS) to identify de novo or inherited variants contributing to the ASD etiology and its associated comorbid conditions in families with complete trios (affected child and the parents).Results: Our analysis revealed 16 CNV regions located in genomic regions implicated in ASD. The analysis of the 88 ASD cases identified 41 genes in 39 ASD subjects with de novo (n = 24) or inherited variants (n = 22). We identified three novel de novo variants in new candidate genes for ASD (DTX4, ARMC6, and B3GNT3). Also, we have identified 15 de novo variants in genes that were previously implicated in ASD or related neurodevelopmental disorders (PHF21A, WASF1, TCF20, DEAF1, MED13, CREBBP, KDM6B,SMURF1, ADNP, CACNA1G, MYT1L, KIF13B, GRIA2, CHM, and KCNK9). Additionally, we defined eight novel recessive variants (RYR2, DNAH3, TSPYL2, UPF3B KDM5C, LYST, and WNK3), four of which were X-linked.Conclusion: Despite the ASD multifactorial etiology that hinders ASD genetic risk discovery, the number of identified novel or known putative ASD genetic variants was appreciable. Nevertheless, this study represents the first comprehensive characterization of ASD genetic risk in Qatar's Middle Eastern population

Concurrent Proinflammatory and Apoptotic Activity of a Helicobacter pylori Protein (HP986) Points to Its Role in Chronic Persistence

Helicobacter pylori induces cytokine mediated changes in gastroduodenal pathophysiology, wherein, the activated macrophages at the sub-mucosal space play a central role in mounting innate immune response against the antigens. The bacterium gains niche through persistent inflammation and local immune-suppression causing peptic ulcer disease or chronic gastritis; the latter being a significant risk factor for the development of gastric adenocarcinoma. What favors persistence of H. pylori in the gastric niches is not clearly understood. We report detailed characterization of a functionally unknown gene (HP986), which was detected in patient isolates associated with peptic ulcer and gastric carcinoma. Expression and purification of recombinant HP986 (rHP986) revealed a novel, ∼29 kDa protein in biologically active form which associates with significant levels of humoral immune responses in diseased individuals (p<0.001). Also, it induced significant levels of TNF-α and Interleukin-8 in cultured human macrophages concurrent to the translocation of nuclear transcription factor-κB (NF-κB). Further, the rHP986 induced apoptosis of cultured macrophages through a Fas mediated pathway. Dissection of the underlying signaling mechanism revealed that rHP986 induces both TNFR1 and Fas expression to lead to apoptosis. We further demonstrated interaction of HP986 with TNFR1 through computational and experimental approaches. Independent proinflammatory and apoptotic responses triggered by rHP986 as shown in this study point to its role, possibly as a survival strategy to gain niche through inflammation and to counter the activated macrophages to avoid clearance