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The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching

Blood vessel formation requires the integrated regulation of endothelial cell proliferation and branching morphogenesis, but how this coordinated regulation is achieved is not well understood. Flt-1 (vascular endothelial growth factor [VEGF] receptor 1) is a high affinity VEGF-A receptor whose loss leads to vessel overgrowth and dysmorphogenesis. We examined the ability of Flt-1 isoform transgenes to rescue the vascular development of embryonic stem cell–derived flt-1−/− mutant vessels. Endothelial proliferation was equivalently rescued by both soluble (sFlt-1) and membrane-tethered (mFlt-1) isoforms, but only sFlt-1 rescued vessel branching. Flk-1 Tyr-1173 phosphorylation was increased in flt-1−/− mutant vessels and partially rescued by the Flt-1 isoform transgenes. sFlt-1–rescued vessels exhibited more heterogeneous levels of pFlk than did mFlt-1–rescued vessels, and reporter gene expression from the flt-1 locus was also heterogeneous in developing vessels. Our data support a model whereby sFlt-1 protein is more efficient than mFlt-1 at amplifying initial expression differences, and these amplified differences set up local discontinuities in VEGF-A ligand availability that are important for proper vessel branching

The Maine Annex, vol. 1, no. 12

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. This issue contains an editorial lamenting the presence of State Police Officers at the Victory Dance the previous weekend. In addition to approximately 250 women bussed in from surrounding communities, blue uniformed proponents of the law were thicker than ants at a picnic

The Maine Annex, vol. 1, no. 13

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Amid the coverage in this issue is a retrospective piece discussing the Brunswick Annex campus at Brunswick Naval Air Base

The Maine Annex, vol. 1, no. 8

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Borrowing from the University of Maine, Orono campus, the Brunswick campus sponsored the election of a student Mayor as part of the spring dance escapades. Promotion of dance night activities includes the promise of plentiful women attending

The Maine Annex, vol. 1, no. 7

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Front-page interests in this issue revolve around sports, women, and the creation of a student dance band, and attracting women to campus by staging dances

The Maine Annex, vol. 1, no. 9

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Coverage in this issue emphasizes Veterans issues, including a story about the distribution of one million surplus textbooks from the Army and Navy special training programs to Veterans attending institutions nationwide

The Maine Annex, vol. 1, no. 11

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned. Page two discussions in this issue orbit the issue of G.I. Subsistence, from James McNiff\u27s article examining the discrepancy between the increased cost of living in the U.S. and the inadequate amount of money allocated through the Veterans subsistence allowance to commentary about the persistently, poor quality of food provided to students by the University in exchange for their money

The Maine Annex, vol. 1, no. 10

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. The start of a funding drive to build the Memorial Union on the University of Maine, Orono campus, is covered in this issue of The Maine Annex. The Union is to be dedicated to 175 UMaine Alumni war dead. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned

The Maine Annex, vol. 1, no. 11

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned. Page two discussions in this issue orbit the issue of G.I. Subsistence, from James McNiff\u27s article examining the discrepancy between the increased cost of living in the U.S. and the inadequate amount of money allocated through the Veterans subsistence allowance to commentary about the persistently, poor quality of food provided to students by the University in exchange for their money