Dynamical structure factor of a fermionic supersolid on an optical lattice

Interfacing unbiased quantum Monte Carlo simulations with state-of-art analytic continuation techniques, we obtain exact numerical results for dynamical density and spin correlations in the attractive Hubbard model, describing a spin-balanced two-dimensional cold Fermi gas on an optical lattice. We focus on half-filling, where on average one fermion occupies each lattice site, and the system displays an intriguing supersolid phase: a superfluid with a checkerboard density modulation. The coexistence of $U(1)$ broken symmetry and the density modulations makes this regime very challenging and interesting for the calculation of dynamical properties. We compare our unbiased results with state-of-the-art Generalized Random Phase Approximation calculations: both approaches agree on a well-defined low-energy Nambu-Goldstone collective mode in the density correlations, while the higher energy structures appear to differ significantly. We also observe an interesting high-energy spin mode. We argue that our results provide a robust benchmark for Generalized Random Phase Approximation techniques, which are widely considered to be the method of choice for dynamical correlations in Fermi gases. Also, our calculations yield new physical insight in the high-energy behavior of the dynamical structure factor of the attractive Hubbard model, which is a well known prototype lattice model for superconductors and is a fertile field to target the observation of collective modes in strongly correlated systems.Comment: 12 pages, 6 figures, post-print versio

La preposición de como inicio de locución: sus patrones y su frecuencia de uso

This paper focuses on the morfosyntactic structure of theadverbial expressions, more spesificly on those that begin withthe preposition de. The material is taken from two dictionaries:one general dictionary, the DRAE and another phraseologicalone, the Diccionario de Locuciones y Expresiones Familiares.Having identified all the relevant structures, we continuedestablishing a functional pattern, which has made it possibleto observe which structures are the productive ones, that canbe used as a base for new examples, and which are lessefficient patterns when when it comes to reproduction andthe creation of new units.O presente trabalho tem por objetivo analisar a estruturamorfosintática das locuções adverbiais, mais concretamentedaquelas iniciadas com a preposição de. Para tanto, a totalidadedas citadas formações pluriverbais foi extraída de dois dicionários: um relacionado à língua espanhola geral, o DRAE,e outro de caráter fraseológico, o Diccionario de Locuciones yExpresiones Familiares. Depois de obtidas todas as estruturas,foram estabelecidos padrões funcionais, o que nos permitiuobservar quais são as estruturas produtivas, e, portanto, servemde base para novas criações, e quais representam padrões poucoeficazes para sua reprodução no processo de criação de novasunidades

Regional Invasive Species & Climate Change Management Challenge: Embracing the Future. Promoting adaptation and resilience to invasive species and climate change

Climate change and invasive species can interact to increase disturbances and magnify changes in ecosystem form and function (Double Trouble). Increasing resilience is one of several management approaches for enabling healthy ecosystems to persist despite these changes. While resilience can be complicated and take many forms, it can generally be thought of as the “ability [of an ecosystem] to experience disturbances or environmental change without changing to a fundamentally different state” [Holling, 1973]. The accumulating effects of climate change, invasive species, or interacting effects of multiple disturbances can push an ecosystem past a tipping point and into a new ecological state. These alternative states are characterized by a different suite of species or functions, which are difficult or impossible to recover from (e.g. a shift from a closed-canopy to an open-canopy forested wetland). Actions to increase resilience help an ecosystem to maintain or return to its fundamental structure or function after a disturbance. Resilience falls in the middle of a spectrum of management goals ranging from preventing change (resistance) to promoting change (transformation) in the species composition, structure, or functions provided by an ecosystem. Clear management goals (See Table) and an understanding of the range of disturbances affecting focal ecosystems are necessary for deciding between managing for resistance, resilience, or transformation and what actions are required for successful management outcomes

Skin Pharmacokinetics of Transdermal Scopolamine:Measurements and Modeling

Prediction of skin absorption and local bioavailability from topical formulations remains a difficult task. An important challenge in forecasting topical bioavailability is the limited information available about local and systemic drug concentrations post application of topical drug products. Commercially available transdermal patches, such as Scopoderm (Novartis Consumer Health UK), offer an opportunity to test these experimental approaches as systemic pharmacokinetic data are available with which to validate a predictive model. The long-term research aim, therefore, is to develop a physiologically based pharmacokinetic model (PBPK) to predict the dermal absorption and disposition of actives included in complex dermatological products. This work explored whetherin vitrorelease and skin permeation tests (IVRT and IVPT, respectively), andin vitroandin vivostratum corneum (SC) and viable tissue (VT) sampling data, can provide a satisfactory description of drug “input rate” into the skin and subsequently into the systemic circulation.In vitrorelease and skin permeation results for scopolamine were consistent with the previously reported performance of the commercial patch investigated. New skin sampling data on the dermatopharmacokinetics (DPK) of scopolamine also accurately reflected the rapid delivery of a “priming” dose from the patch adhesive, superimposed on a slower, rate-controlled input from the drug reservoir. The scopolamine concentration versus time profiles in SC and VT skin compartments,in vitroandin vivo, taken together with IVRT release and IVPT penetration kinetics, reflect the input rate and drug delivery specifications of the Scopoderm transdermal patch and reveal the importance of skin binding with respect to local drug disposition. Further data analysis and skin PK modeling are indicated to further refine and develop the approach outlined.</p

The seventh international RASopathies symposium: Pathways to a cure—expanding knowledge, enhancing research, and therapeutic discovery

RASopathies are a group of genetic disorders that are caused by genes that affect the canonical Ras/mitogen-activated protein kinase (MAPK) signaling pathway. Despite tremendous progress in understanding the molecular consequences of these genetic anomalies, little movement has been made in translating these findings to the clinic. This year, the seventh International RASopathies Symposium focused on expanding the research knowledge that we have gained over the years to enhance new discoveries in the field, ones that we hope can lead to effective therapeutic treatments. Indeed, for the first time, research efforts are finally being translated to the clinic, with compassionate use of Ras/MAPK pathway inhibitors for the treatment of RASopathies. This biannual meeting, organized by the RASopathies Network, brought together basic scientists, clinicians, clinician scientists, patients, advocates, and their families, as well as representatives from pharmaceutical companies and the National Institutes of Health. A history of RASopathy gene discovery, identification of new disease genes, and the latest research, both at the bench and in the clinic, were discussed

Strengthening the development of the short-rotation plantations bioenergy sector: Policy insights from six European countries

This paper, based on a participatory methodological framework involving expert stakeholders and researchers from six European countries (Germany, Ireland, Poland, Spain, Sweden and UK), analyses the priority issues for the development of short-rotation plantations (SRP), and proposes a series of policy strategies to strengthen this development. The results indicate that there is a lack of awareness of the multifaceted benefits of SRP at the level of farmers, policy makers and public authorities. More research is required to put a value on the multifunctionality of SRP and justify its public support. Small-scale projects using established technologies are also required with energy crops introduced in a phased manner. The simultaneous dissemination of this knowledge upwards to policy makers and downwards to producers and farmers is critical in the success of SRP. Also, greater financial support on both the supply and demand side is highlighted as being necessary: on the supply side linking multifunctional benefits of SRP and targeted payments, along with increased long-term contractual arrangements between farmers and energy plant operators; demand side incentives should overcome any difference in price between fossil fuels and energy crops. Groups to lobby for the uptake and support of SRP and bioenergy are also of necessary