A Problemática da tradução no curso de Línguas e Secretariado do ISCAP

Polissema: Revista de Letras do ISCAP 2001/N.º 1 - TraduçãoO curso de Línguas e Secretariado que abarca, na primeira etapa da Licenciatura, as duas vertentes, divide-se em dois ramos, na segunda; neste prolongamento temos, por um lado, a tradução especializada para a área das línguas e, por outro, o secretariado de gestão na área do secretariado. Logicamente, a opção entre estas duas hipóteses é feita pelos próprios alunos, mas de acordo com as aptidões e capacidades demonstradas durante a primeira etapa do curso. No nosso caso, como somos professoras de Língua Materna e estrangeira (francês), debruçar-nosemos sobre a problemática do ensino das línguas e, logo, da tradução em termos gerais para, de seguida, abordarmos a tradução especializada

Clean and efficient energies for Europe : socio-economic impact of energy research

Report of the independent expert panelLaunched in 1994, the Fourth Framework Programme (FP4) covering research and demonstration aimed to improve the security of energy supply and to reduce the impact of the production and use of energy on the environment, in particular CO2 and the other greenhouse gases. Other important EU objectives were also addressed including strengthening the technological basis of the energy industry (e.g. employment and export potential), improving European social and economic cohesion and contributing to co-operation with third countries. It also supported research on overall energy RTD strategy in the inter-disciplinary area of energy-environment-economy. Six years after the Programme’s launch, at a stage when most of the projects have been completed, and the Sixth Framework Programme is being planned, it was considered appropriate to assess not only the scientific and technical quality of the completed projects, but also their impact on society, the economy and the environment. The present analysis was organised to allow quick feedback for the preparation of the new Framework Programme. This was achieved by convening a panel of ten experts from different Member States. Using questionnaires, project final reports and direct contacts where necessary, the Panel investigated the expected overall impact by examining the scientific and technical results as well as the social and economic impact of a sample of about 90 already finished Non-Nuclear Energy projects, most of them three years ago (time necessary to expect some concrete results), representing in total a e84 million investment by the Commission. The contribution to Community policies, particularly emphasised in the present Framework Programme, as well as the Programmes’s addition to European Added Value were both explored. The results of this impact assessment of about one-fifth of the projects funded under the Non-Nuclear Energy Programme of the Fourth Framework Programme for the period 1994-1998 (better known as JOULE), were analysed and critically reviewed and are presented in this report. Among the main conclusions of the report, it is worth noting that the vast majority of the examined projects have developed new technical advances. Furthermore, the commercial leverage of funded research projects is positive and its major non-commercial impact is on the improvement of the environment and particularly on CO2 emissions. The social and economic impact remains, in general, limited, but could be improved through better understanding and application of the European Added Value principles. The Fifth Framework Programme made a further step towards refocusing European energy research and aiming to provide effective responses to the major challenges facing European society. It is important to fully exploit the experience and the results from the research undertaken under the FP4 since the knowledge generated relates directly to the objectives of the next Energy Research Programme. It also provides the groundwork for launching effective and innovative approaches to implementing the “European Research Area”. Based on the present pilot exercise, the remaining projects of the Non-Nuclear Energy Programme of the FP4 will be assessed to provide a full picture of the impact of the Programme. Finally, the present pilot exercise should help to provide a methodological base for other research programmes to develop quick-response, feedback to decision-makers to allow for the development of better informed research policies and actions. It should also help to bring more quickly the results and socio-economic implications of European research to European citizens, companies and institutions

First two unrelated cases of isolated sedoheptulokinase deficiency: A benign disorder?

We present the first two reported unrelated patients with an isolated sedoheptulokinase (SHPK) deficiency. The first patient presented with neonatal cholestasis, hypoglycemia, and anemia, while the second patient presented with congenital arthrogryposis multiplex, multiple contractures, and dysmorphisms. Both patients had elevated excretion of erythritol and sedoheptulose, and each had a homozygous nonsense mutation in SHPK. SHPK is an enzyme that phosphorylates sedoheptulose to sedoheptulose-7-phosphate, which is an important intermediate of the pentose phosphate pathway. It is questionable whether SHPK deficiency is a causal factor for the clinical phenotypes of our patients. This study illustrates the necessity of extensive functional and clinical workup for interpreting a novel variant, including nonsense variants

Reviewing progress: 7 Year Trends in Characteristics of Adults and Children Enrolled at HIV Care and Treatment Clinics in the United Republic of Tanzania.

To evaluate the on-going scale-up of HIV programs, we assessed trends in patient characteristics at enrolment and ART initiation over 7 years of implementation. Data were from Optimal Models, a prospective open cohort study of HIV-infected (HIV+) adults (>=15 years) and children (<15 years) enrolled from January 2005 to December 2011 at 44 HIV clinics in 3 regions of mainland Tanzania (Kagera, Kigoma, Pwani) and Zanzibar. Comparative statistics for trends in characteristics of patients enrolled in 2005--2007, 2008--2009 and 2010--2011 were examined. Overall 62,801 HIV+ patients were enrolled: 58,102(92.5%) adults, (66.5% female); 4,699(7.5%) children.Among adults, pregnant women enrolment increased: 6.8%, 2005--2007; 12.1%, 2008--2009; 17.2%, 2010--2011; as did entry into care from prevention of mother-to-child HIV transmission (PMTCT) programs: 6.6%, 2005--2007; 9.5%, 2008--2009; 12.6%, 2010--2011. WHO stage IV at enrolment declined: 27.1%, 2005--2007; 20.2%, 2008--2009; 11.1% 2010--2011. Of the 42.5% and 29.5% with CD4+ data at enrolment and ART initiation respectively, median CD4+ count increased: 210cells/muL, 2005--2007; 262cells/muL, 2008--2009; 266cells/muL 2010--2011; but median CD4+ at ART initiation did not change (148cells/muL overall). Stavudine initiation declined: 84.9%, 2005--2007; 43.1%, 2008--2009; 19.7%, 2010--2011.Among children, median age (years) at enrolment decreased from 6.1(IQR:2.7-10.0) in 2005--2007 to 4.8(IQR:1.9-8.6) in 2008--2009, and 4.1(IQR:1.5-8.1) in 2010--2011 and children <24 months increased from 18.5% to 26.1% and 31.5% respectively. Entry from PMTCT was 7.0%, 2005--2007; 10.7%, 2008--2009; 15.0%, 2010--2011. WHO stage IV at enrolment declined from 22.9%, 2005--2007, to 18.3%, 2008--2009 to 13.9%, 2010--2011. Proportion initiating stavudine was 39.8% 2005--2007; 39.5%, 2008--2009; 26.1%, 2010--2011. Median age at ART initiation also declined significantly. Over time, the proportion of pregnant women and of adults and children enrolled from PMTCT programs increased. There was a decline in adults and children with advanced HIV disease at enrolment and initiation of stavudine. Pediatric age at enrolment and ART initiation declined. Results suggest HIV program maturation from an emergency response

Individual common variants exert weak effects on the risk for autism spectrum disorders.

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm&lt; 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest

Meta-analysis quantifying the potential of dietary additives and rumen modifiers for methane mitigation in ruminant production systems

Increasingly countries are seeking to reduce emission of greenhouse gases from the agricultural industries, and livestock production in particular, as part of their climate change management. While many reviews update progress in mitigation research, a quantitative assessment of the efficacy and performance-consequences of nutritional strategies to mitigate enteric methane (CH4) emissions from ruminants has been lacking. A meta-analysis was conducted based on 108 refereed papers from recent animal studies (2000-2020) to report effects on CH4 production, CH4 yield and CH4 emission intensity from 8 dietary interventions. The interventions (oils, microalgae, nitrate, ionophores, protozoal control, phytochemicals, essential oils and 3-nitrooxypropanol). Of these, macroalgae and 3-nitrooxypropanol showed greatest efficacy in reducing CH4 yield (g CH4/kg of dry matter intake) at the doses trialled. The confidence intervals derived for the mitigation efficacies could be applied to estimate the potential to reduce national livestock emissions through the implementation of these dietary interventions

A problemática da tradução do Curso de Linguas e Secretariado do ISCAP

O curso de Línguas e Secretariado que abarca, na primeira etapa da Licenciatura, as duas vertentes, divide-se em dois ramos, na segunda; neste prolongamento temos, por um lado, a tradução especializada para a área das línguas e, por outro, o secretariado de gestão na área do secretariado. Logicamente, a opção entre estas duas hipóteses é feita pelos próprios alunos, mas de acordo com as aptidões e capacidades demonstradas durante a primeira etapa do curso. No nosso caso, como somos professoras de Língua Materna e estrangeira (francês), debruçar-nosemos sobre a problemática do ensino das línguas e, logo, da tradução em termos gerais para, de seguida, abordarmos a tradução especializad

IMMU-23. A NOVEL MASS CYTOMETRY-BASED MULTI-PARAMETER CHARACTERIZATION OF NEOANTIGEN-REACTIVE CD8+ T-CELLS IN PATIENTS PARTICIPATING IN PNOC007 H3.3K27M PEPTIDE VACCINE CLINICAL TRIAL

Abstract BACKGROUND We have identified an HLA-A*02:01-restricted neoantigen epitope encompassing the H3.3K27M mutation and implemented a multi-center clinical trial of the peptide vaccine through the Pacific Pediatric Neuro-Oncology Consortium (PNOC007) for patients with diffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG). We sought to characterize vaccine-reactive CD8+T-cells subpopulations using their precise activation and developmental status to find their associations with clinical outcomes. METHODS Mass cytometry (CyTOF) analysis was performed on patient-derived peripheral blood mononuclear cells collected at baseline as well as pre-specified time points throughout the study. Each cell subtype was characterized via tSNE-clustering based on their expression profiles and quantified as a fraction of total CD45+cells. H3.3K27M-reactive CD8+T-cells were evaluated using an H3.3K27M-HLA-A2 dextramer along with a panel of T-cell and myeloid markers. RESULTS Among all 29 patients enrolled, we analyzed samples from all 19 DIPG and 9 of 10 non-brainstem DMG cases, of which 18 had longitudinal samples available (range: 2–5). Utilizing a novel CyTOF-based immuno-monitoring platform, the expansion of H3.3K27M-reactive CD8+T-cells, defined as a 25% increase at any time-point relative to baseline, was observed in 7 of these 18 patients. Survival analyses indicated that the expansion of H3.3K27M-reactive CD8+T-cells, particularly the effector-memory phenotype, positively correlated with longer overall survival (OS) (median: 16.1 vs 9.7 months, p=0.03), whereas an abundance of early and monocytic myeloid-derived suppressor cells at baseline correlated with shorter OS among DIPG patients (9.5 vs 14.3 months, p=0.002). CONCLUSION Our novel immuno-monitoring approach offers insight into how vaccine-induced immune responses impact clinical outcomes