Distribution of reported single nucleotide polymorphisms (SNPs) throughout the <i>pncA</i> gene.

<p>Dashed lines indicate the open reading frame for the <i>pncA</i> gene.</p

Flow diagram describing article selection.

<p>Flow diagram describing article selection.</p

Forest plot for the summary estimates of pyrazinamide prevalence by WHO region and presence or risk of MDR-TB.

<p>Abbreviations: CI, confidence interval; DST, drug susceptibility test; MDR-TB, multi-drug resistant tuberculosis; N/A, not applicable; WHO, world health organization. MDR-TB was defined as an isolate being resistant to RIF and INH. High risk of MDR-TB was defined as an isolate being resistant to at least one anti-TB drug. *Any TB was defined as the inclusion of patients independent of drug resistance profile.</p

Global distribution of included studies.

<p>Countries are shaded if a study was included in this review.</p

Estimated annual burden of new PZA resistant tuberculosis cases, overall and among MDR-TB patients, globally and by WHO region.

<p>Abbreviations: MDR-TB, multi-drug resistant tuberculosis; PZA, pyrazinamide; TB, tuberculosis; WHO, World Health Organization.</p><p>* Incidence of TB cases from the World Health Organization Global Tuberculosis Report 2014.</p><p>Estimated annual burden of new PZA resistant tuberculosis cases, overall and among MDR-TB patients, globally and by WHO region.</p