Associations of observed confounders with <i>ADH1B</i> and <i>ADH1C</i> genotype.

<p><b>N = 58,313</b>.</p>a<p>F-statistic for continuous variables and chi-square for categorical variables testing the null hypothesis that distributions of the confounders do not differ by genotype (1 degree of freedom for <i>ADH1B</i> and 2 degrees of freedom for <i>ADH1C</i>).</p><p>MVPA = Moderate or vigorous physical activity. Kr = Danish kroner.</p><p>Associations of observed confounders with <i>ADH1B</i> and <i>ADH1C</i> genotype.</p

Association of <i>ADH1B</i> and <i>ADH1C</i> with alcohol consumption.

<p>OR: Odds ratio; CI: confidence intervals.</p>a<p>From a model of the mean risk difference of not drinking.</p><p>Association of <i>ADH1B</i> and <i>ADH1C</i> with alcohol consumption.</p

Confounder adjusted multivariable and instrumental variable associations of alcohol with biomarkers of liver function in those who report some alcohol consumption (i.e. those reporting no consumption have been removed from these analyses).

<p>CI: confidence interval; ALT: alanine aminotransferase; γ-GT: γ-glutamyl-transferase; ALP: alkaline phosphatase; Prothrombin: Prothrombin action.</p><p>In the multivariable analysis all results are adjusted for age, gender, smoking, physical activity, education and income.</p><p>In the instrumental variable analysis the control function method was used with <i>ADH1B</i> and <i>ADH1C</i> used jointly as categorical (indicator) instrumental variables. The first stage F-statistic for all instrumental variable analyses = 34.</p>a<p>Test of null hypothesis that there is no difference in association of alcohol with each outcome between the confounder adjusted multivariable association (row 1) and the instrumental variable association using the control function (row 2); p-value obtained from the bootstrap distribution.</p><p>Confounder adjusted multivariable and instrumental variable associations of alcohol with biomarkers of liver function in those who report some alcohol consumption (i.e. those reporting no consumption have been removed from these analyses).</p

Confounder adjusted multivariable and instrumental variable associations of drinking versus not drinking alcohol with biomarkers for liver function.

<p>CI: confidence interval; ALT: alanine aminotransferase; γ-GT: γ-glutamyl-transferase; ALP: alkaline phosphatase; Prothrombin: Prothrombin action.</p><p>In the multivariable analysis all results are adjusted for age, gender, smoking, physical activity, education and income.</p><p>In the instrumental variable analysis the control function method was used with <i>ADH1B</i> and <i>ADH1C</i> used jointly as categorical (indicator) instrumental variables. The first stage F-statistic for all instrumental variable analyses = 21.</p>a<p>Test of null hypothesis that there is no difference in association of alcohol with each outcome between the confounder adjusted multivariable association (row 1) and the instrumental variable association using the control function (row 2); p-value obtained from the bootstrap distribution.</p><p>Confounder adjusted multivariable and instrumental variable associations of drinking versus not drinking alcohol with biomarkers for liver function.</p