Various explorations conducted in a patient with osteosarcoma of the right upper arm.

<p>A 14-year-old girl with osteosarcoma of the right upper arm visualized by FDG-PET scans acquired before chemotherapy (A) and after chemotherapy (B) (left column, coronal view of PET; second column, fused PET/CT; third column, CT images; fourth column, the maximum intensity projections of PET; right column, local MRI unenhanced T1- weighted). After neoadjuvant chemotherapy (B), local MRI showed a stable tumor size and FDG-PET remained similar to baseline. Despite this stable disease on imaging, the removed tumor specimen (C) was almost completely composed of necrotic tissue (96%).</p

Prognostic values (<i>p value</i> and <i>Hazard Ratios</i> when p-value < 0.05) of classical prognostic factors derived from initial staging and of metrics derived from initial FDG-PET, on univariate analysis.

<p>Prognostic values (<i>p value</i> and <i>Hazard Ratios</i> when p-value < 0.05) of classical prognostic factors derived from initial staging and of metrics derived from initial FDG-PET, on univariate analysis.</p

List of heterogeneity and shape indices.

<p>List of heterogeneity and shape indices.</p

Prognostic values (<i>p value</i> and <i>Hazard Ratios</i> when significant p-value) of classical prognostic factors derived from initial staging and of metrics derived from initial FDG-PET, on multivariate analysis.

<p>Prognostic values (<i>p value</i> and <i>Hazard Ratios</i> when significant p-value) of classical prognostic factors derived from initial staging and of metrics derived from initial FDG-PET, on multivariate analysis.</p

Semi-quantitative metrics derived from post-CHT FDG-PET.

<p>Semi-quantitative metrics derived from post-CHT FDG-PET.</p

Patients’ characteristics.

<p>Patients’ characteristics.</p

Various explorations conducted in a patient with osteosarcoma of the right tibia.

<p>FDG-PET scans acquired before (A) and after chemotherapy (B) in a patient with osteosarcoma of the right tibia. The maximum intensity projections of PET (first columns) and the coronal views of fused PET/CT images (third columns) showed evident significant reduction in MTV (second columns) using an adaptative threshold, after chemotherapy. The removed tumor specimen (C) was almost completely composed of necrotic tissue (99%).</p

Semi-quantitative metrics derived from initial FDG-PET.

<p>Semi-quantitative metrics derived from initial FDG-PET.</p

Additional file 1: of New somatic BRAF splicing mutation in Langerhans cell histiocytosis

Supplemental methods and data. (DOCX 904 kb

Additional file 1: of Outcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study

Outcome of patients admitted to the ICU for acute manifestation of small-vessel vasculitis. (DOCX 23 kb