The plasma level of sICAM-1 expressed as mean ±SEM of <i>n</i> = 8–12.

<p>**p<0.01 HIV-1Tg vs. control rats.</p

Gene expression relative to the calibrator (RQC) expressed as mean ±SEM of <i>n</i> = 8–12.

<p>(A) LOX-1: *<i>p</i><0.05 aortic arch, HIV-1Tg vs. control rats; ^Δ<i>p</i><0.05 control rats, aortic arch vs. abdominal aorta. (B) VCAM-1: *<i>p</i><0.05 aortic arch, HIV-1Tg vs. control rats; ^Δ<i>p</i><0.05 HIV-1Tg rats, aortic arch vs. abdominal aorta. (C) ICAM-1: ^ΔΔΔ<i>p</i><0.001 control rats, aortic arch vs. abdominal aorta.</p

Optimal filter setting, primer- and probe-concentration for the genes investigated.

<p>Optimal filter setting, primer- and probe-concentration for the genes investigated.</p

PET uptake in H727 xenografts.

<p>Uptake of FDG (upper panel) and FLT (lower panel) after treatment of H727 xenografts with everolimus or vehicle. N = 8–10 tumors/group. *) P<0.05 vs. control group on same day, #) P<0.05 and ##) P<0.01 vs. baseline of same group. P-values are Bonferroni corrected.</p

MTT Assay.

<p><i>In vitro</i> inhibition of neuroendocrine tumor cell proliferation by everolimus using MTT assay.</p

Study design.

<p>Study design.</p

Early PET correlated to later tumorgrowth.

<p>Correlations of individual tumor uptake (SUVmean) day 1 and day 3 and subsequent tumor growth until day 7 and 10. Left panel: mean uptake of FDG at day 3 correlated significantly with tumor growth until day 10, (n = 10). Right panel: mean uptake of FLT at day 1 correlated significantly with tumor growth until day 7 and FLT uptake at day 3 correlated with tumor growth until both day 7 and 10 (n = 8 tumors). Tumor growth is expressed as volume relative to baseline, 95% confidence intervals are shown. Correlations with SUVmax show same trend (not shown).</p

Univariate linear regression analyses of gene expression relative to ¹⁸F-FDG SUV_mean.

<p>All <i>p</i>-values were Bonferroni corrected.</p

Primers and probes.

<p>Primers and probes.</p

Selection of ROIs.

<p><b>A</b> Fused PET/CT image, axial view. <b>B</b> Fused PET/CT image with ROI drawn, axial view. <b>C</b> Fused PET/CT image with the ROIs after ROI interpolation, sagittal view. Most, but not the entire aorta is visible.</p