15 research outputs found
Additional file 16: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Venn diagram of differentially expressed genes (CONV-R versus GF) that also contain DMPs within a 5-kb window. (PDF 377Â kb
Additional file 6: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Gene ontology (GO) analysis of the microbially regulated genes from each developmental stage. (XLSX 39Â kb
Additional file 9: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Heatmap of developmentally regulated genes (n = 553 genes). (PDF 818 kb
Additional file 5: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
MA transcriptome plot for CONV-R versus GF comparison. Every dot represents one transcript. The x-axis denotes the mean expression value and the y-axis denotes the log2 fold change of CONV-R versus GF. Red dots indicate statistically significant transcripts (CONV-R versus GF, adjusted p value < 0.05). The ceiling/floor of two on log2 fold change (y-axis) is set because of better visualization. (PDF 632 kb
Additional file 15: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Heatmap of methylation levels for developmentally related methylation sites. (PDF 658Â kb
Additional file 4: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Gene expression data of small intestinal epithelial cells from germ-free (GF) and conventionally raised (CONV-R) mice at the three developmental stages W1, W4, and W12/16 determined by RNA sequencing. (XLSX 9442Â kb
Additional file 18: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Gene expression and DNA methylation levels of Mob3b (MOB kinase activator 3B) and Ube2a (Ubiquitin conjugating enzyme E2 A) genes and genomic loci in CONV-R and GF mice during postnatal development. (PDF 438Â kb
Additional file 12: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Genomic location of DMPs (CONV-R versus GF) in the three developmental stages. (PDF 384Â kb
Additional file 1: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
List of primers used for validation experiment (qPCR and amplicon sequencing). (XLSX 49Â kb
Additional file 11: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Methylation levels across all samples (median ± standard deviation). (PDF 384 kb