Hawaiian Nightingale : Waltz

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PUBLIC SPACE \\ THE INTERNET: Public Embodiment of Digital Cultures

Public space is vital to urban society because it lies at the center of social and cultural life, however today the internet acts as a new centrality where interaction and socialization occur in a new invisible setting. Today both physical and digital public space serve as a vital interface for civic engagement and public participation, yet there is much content that often only remains significant on the internet. This thesis seeks to both strengthen the significance of our online public interactions and enliven the urban public realm by translating digital cultures into the urban environment, giving content the ability to flow between both worlds. This hypothesis will be tested through the redesign of Pershing Square in Downtown, Los Angeles, CA

An Evolution in Research Practice for Investigating International Business Relationships

The purpose of this paper is to discuss the development and rationale of research methodology for a specific topic of research. The topic in question is an investigation into international business relationships, a complex subject and one that is very topical in the growing world of international business. It is intended to examine the logical development of research practice in our study and to show the changing thought processes and justifications we have made over a period of time. It is hoped that this discussion paper will be helpful to academics and students alike, as so often research methodology is only discussed in terms of the final method/techniques chosen with an emphasis on the technical aspects of the methods rather than relating them to the subject to be researched

Improving infant sleep and maternal mental health: a cluster randomised trial

Objectives: To determine whether a community-delivered intervention targeting infant sleep problems improves infant sleep and maternal well-being and to report the costs of this approach to the healthcare system. Design: Cluster randomised trial. Setting: 49 Maternal and Child Health (MCH) centres (clusters) in Melbourne, Australia. Participants: 328 mothers reporting an infant sleep problem at 7 months recruited during October&ndash;November 2003. Intervention: Behavioural strategies delivered over individual structured MCH consultations versus usual care. Main outcome measures: Maternal report of infant sleep problem, depression symptoms (Edinburgh Postnatal Depression Scale (EPDS)), and SF-12 mental and physical health scores when infants were 10 and 12 months old. Costs included MCH sleep consultations, other healthcare services and intervention costs. Results: Prevalence of infant sleep problems was lower in the intervention than control group at 10 months (56% vs 68%; adjusted OR 0.58 (95% CI: 0.36 to 0.94)) and 12 months (39% vs 55%; adjusted OR 0.50 (0.31 to 0.80)). EPDS scores indicated less depression at 10 months (adjusted mean difference &ndash;1.4 (&ndash;2.3 to &ndash;0.4) and 12 months (&ndash;1.7 (&ndash;2.6 to &ndash;0.7)). SF-12 mental health scores indicated better health at 10 months (adjusted mean difference 3.7 (1.5 to 5.8)) and 12 months (3.9 (1.8 to 6.1)). Total mean costs including intervention design, delivery and use of non-MCH nurse services were &pound;96.93 and &pound;116.79 per intervention and control family, respectively. Conclusions: Implementing this sleep intervention may lead to health gains for infants and mothers and resource savings for the healthcare system.<br /

Contributions of photoautotrophy and heterotrophy to the carbon and nitrogen nutrition of Anthopleura elegantissima in three symbiotic states

The Pacific coast sea anemone Anthopleura elegantissima is an excellent model organism for the study of temperate symbiosis due to its unique relationship with two microalgal symbionts, Elliptochloris marina and Symbiodinium spp. In addition to hosting one or both of these symbionts, A. elegantissima can live aposymbiotically, allowing for the comparison of nutritional compositions of hosts with different symbionts. This study used stable isotope analysis to quantify the photoautotrophic contributions by symbionts and heterotrophic contributions by hosts. Algal, anemone-only, and algae+anemone samples were isolated from A. elegantissima symbiotic with E. marina, Symbiodinium spp., or anemones lacking symbionts. Samples were analyzed for δ¹⁵N and δ¹³C in the OSU Stable Isotope Laboratory. Isotope analysis showed that symbiotic anemone-only and algae+anemone samples were very close to the high δ¹⁵N and δ¹³C values of aposymbiotic samples, while algal samples were much lower. These results indicate that symbiotic anemones are relying primarily on heterotrophic nutrition, and receiving little-to-no benefit from hosting either E. marina or Symbiodinium spp. Key Words: Anthopleura elegantissima, Elliptochoris marina, Symbiodinium, stable isotop

Dissecting Galaxies: Separating Star Formation, Shock Excitation and AGN Activity in the Central Region of NGC 613

The most rapidly evolving regions of galaxies often display complex optical spectra with emission lines excited by massive stars, shocks and accretion onto supermassive black holes. Standard calibrations (such as for the star formation rate) cannot be applied to such mixed spectra. In this paper we isolate the contributions of star formation, shock excitation and active galactic nucleus (AGN) activity to the emission line luminosities of individual spatially resolved regions across the central 3 $\times$ 3 kpc$^2$ region of the active barred spiral galaxy NGC$\sim$613. The star formation rate and AGN luminosity calculated from the decomposed emission line maps are in close agreement with independent estimates from data at other wavelengths. The star formation component traces the B-band stellar continuum emission, and the AGN component forms an ionization cone which is aligned with the nuclear radio jet. The optical line emission associated with shock excitation is cospatial with strong $H_2$ and [Fe II] emission and with regions of high ionized gas velocity dispersion ($\sigma > 100$ km s$^{-1}$). The shock component also traces the outer boundary of the AGN ionization cone and may therefore be produced by outflowing material interacting with the surrounding interstellar medium. Our decomposition method makes it possible to determine the properties of star formation, shock excitation and AGN activity from optical spectra, without contamination from other ionization mechanisms.Comment: 16 pages, 12 figures. Accepted for publication in MNRA

Developing a care pathway for advance decisions and powers of attorney: qualitative study

Background. The Mental Capacity Act for England and Wales empowers individuals to plan ahead for when they may lack capacity. Aims. To develop a care pathway for advance decisions and powers of attorney using Huntington’s disease as an exemplar. Method. Qualitative study using in-depth individual interviews with service users and carers, and focus groups with professionals. Inductive qualitative analysis was used to develop themes to construct a care pathway that was then piloted and further evaluated to achieve a final pathway. Results. A care pathway was developed that incorporated an early introduction through a formal education session and a minimum of two sessions separated by at least 2 weeks before advance decision completion. Optimal delivery of this intervention requires significant clinical and administrative commitment. Conclusions. We have developed a simple, easy-to-follow care pathway that was acceptable to users and providers

Turoctocog alfa pegol provides effective management for major and minor surgical procedures in patients across all age groups with severe haemophilia A:Full data set from the pathfinder 3 and 5 phase III trials

Introduction Turoctocog alfa pegol is a glycoPEGylated recombinant factor VIII (FVIII) with an extended half-life developed for prophylaxis, treatment of bleeds and perioperative management in patients with haemophilia A. Aim Evaluate the efficacy and safety of turoctocog alfa pegol treatment for major and minor surgeries in the pathfinder 3 and 5 phase III trials. Methods Adults/adolescents aged >= 12 years with severe haemophilia A (FVIII 80% during major surgery (pathfinder 3). The primary end point was haemostatic efficacy during surgery; secondary end points were blood loss, haemostatic effect postsurgery, consumption, transfusions, safety and health economics. Children (0-11 years) undergoing minor surgeries received 20-75 IU/kg turoctocog alfa pegol at Investigator's discretion (pathfinder 5). Results pathfinder 3 included 35 patients undergoing 49 major surgeries. Haemostasis was successful in 47/49 (95.9%) surgeries; two had moderate haemostatic responses. Median (mean) blood loss during major surgery was 75 (322.6) mL. Four bleeds were reported postsurgery; three were successfully treated with turoctocog alfa pegol (one was not evaluated). On the day of surgery, overall mean (median) dose was 75.5 (74.5) IU/kg and mean (median) number of doses was 1.7 (2.0). Five procedures required 11 transfusions on the day of surgery or days 1-6. No safety concerns or inhibitors were identified. Forty-five minor surgeries in 23 children were performed without complications. Conclusion Turoctocog alfa pegol was effective for perioperative haemostatic management of major and minor surgeries in patients across age groups with severe haemophilia A