Association between the number of domains with problems at baseline and scores on the health indicators.

<p>Association between the number of domains with problems at baseline and scores on the health indicators.</p

Flowchart of the study participants.

<p>Flowchart of the study participants.</p

Effect of the number of domains with problems on health indicators at 12-month follow-up (n = 2172)^*.

<p>Effect of the number of domains with problems on health indicators at 12-month follow-up (n = 2172)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121013#t003fn001" target="_blank">*</a>}.</p

Baseline characteristics of the total study population and stratified for the number of domains with problems.

<p>Baseline characteristics of the total study population and stratified for the number of domains with problems.</p

Association between number of self-reported hindering complaints and functional outcomes in older persons, crude and adjusted for age and sex.

<p>a Adjusted for age and sex</p><p>Abbreviations: GARS = Groningen Activities Restriction Scale; QoL = quality of life; MMSE = Mini Mental State Examination; GDS-15 = Geriatric Depression Scale– 15 items; DJG = De Jong Gierveld loneliness scale</p><p>Association between number of self-reported hindering complaints and functional outcomes in older persons, crude and adjusted for age and sex.</p

Number of self-reported hindering complaints depending on patient characteristics in older persons, stratified for sex (n = 7285).

<p>^a Mann-Whitney U</p><p>^bJonckheere-Terpstra</p><p>Number of self-reported hindering complaints depending on patient characteristics in older persons, stratified for sex (n = 7285).</p

Baseline characteristics of the study population (n = 7285).

<p>Baseline characteristics of the study population (n = 7285).</p

All-cause and cause-specific absolute and relative mortality risk stratified for sex-dependent quartiles of the laboratory profile, IADL disability score and 6-meter gait speed.

<p>Abbreviations: CI, confidence interval; IADL, instrumental activities of daily living.</p><p>Gait speed and IADL disability were divided into sex-dependent quartiles.</p><p>25th, 50th and 75th percentile limits of laboratory measurements stratified for sex;</p><p>Gait speed: male 1.37–1.81–2.91 m/s; female 1.61–2.15–3.95 m/s.</p><p>IADL disability score: male 11–17–25 points; female 12–19–29 points.</p

Kaplan Meier cumulative mortality curves for all cause mortality according to the three models.

<p>(A) laboratory profile based on sex specific quartiles of the seven included laboratory values, (B) sex specific quartiles of gait speed and (C) sex specific quartiles of instrumental activities of daily living (IADL) at age 85 years. <b>A </b><b>- - -</b> no laboratory abnormalities n = 144, <b>-----</b>1 laboratory abnormality n = 165, <b>-----</b>2–4 laboratory abnormalities n = 216, <b>-----</b>5–7 laboratory abnormalities n = 37. <b>B - - -</b> 6-meter gait speed male 0.69 –1.37 m/s; female 0.89–1.61 m/s n = 139, <b>-----</b> 6-meter gait speed male 1.38–1.81 m/s; female 1.61–2.15 m/s n = 142, <b>-----</b> 6-meter gait speed male 1.81–2.81 m/s; female 2.16–3.95 n = 141, <b>-----</b>6-meter gait speed male 2.91–13.0 m/s; female 4.00–13.00 m/s n = 140. <b>C - - -</b> IADL-score male 9–11; female 9–12 n = 136, <b>-----</b> IADL-score male 12–16; female 13–18 n = 141, <b>-----</b> IADL-score male 17–24; female 19–28 n = 145, <b>-----</b> IADL-score male 25–36; female 29–36 n = 139.</p

Baseline characteristics of the study population at age 85 years stratified according to the number of abnormal laboratory results.

<p>Continuous data are presented as median (IQR); p for trend values were obtained by Jonckheere Terpstra tests.</p><p>Categorical data are presented as number (%); p for trend values were obtained by Linear by Linear tests.</p>*<p>cancer, myocardial infarction, stroke, dementia, diabetes, chronic obstructive pulmonary disease, Parkinson’s disease, hip fracture, arthritis.</p