Saturated gain spectrum of VECSELs determined by transient measurement of lasing onset

We describe time-resolved measurements of the evolution of the spectrum of radiation emitted by an optically-pumped continuous-wave InGaAs-GaAs quantum well laser, recorded as lasing builds up from noise to steady state. We extract a fitting parameter corresponding to the gain dispersion of the parabolic spectrum equal to ?79 ± 30 fs2 and ?36 ± 6 fs2 for a resonant and anti-resonant structure, respectively. Furthermore the recorded evolution of the spectrum allows for the calculation of an effective FWHM gain bandwidth for each structure, of 11 nm and 18 nm, respectively

175 GHz, 400-fs-pulse harmonically mode-locked surface emitting semiconductor laser

We report a harmonically mode-locked vertical external cavity surface emitting laser (VECSEL) producing 400 fs pulses at a repetition frequency of 175 GHz with an average output power of 300 mW. Harmonic mode-locking was established using a 300 µm thick intracavity single crystal diamond heat spreader in thermal contact with the front surface of the gain sample using liquid capillary bonding. The repetition frequency was set by the diamond microcavity and stable harmonic mode locking was achieved when the laser cavity length was tuned so that the laser operated on the 117th harmonic of the fundamental cavity. When an etalon placed intracavity next to the gain sample, but not in thermal contact was used pulse groups were observed. These contained 300 fs pulses with a spacing of 5.9 ps. We conclude that to achieve stable harmonic mode locking at repetition frequencies in the 100s of GHz range in a VECSEL there is a threshold pulse energy above which harmonic mode locking is achieved and below which groups of pulses are observed

Simulation of metallic nanostructures for emission of THz radiation using the lateral photo-Dember effect

A 2D simulation for the lateral photo-Dember effect is used to calculate the THz emission of metallic nanostructures due to ultrafast diffusion of carriers in order to realize a series of THz emitters.Comment: Corrected version of a paper given at 2011 36th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz

Photon-pair generation in photonic crystal fibre with a 1.5 GHz modelocked VECSEL

Four-wave mixing (FWM) in optical fibre is a leading technique for generating high-quality photon pairs. We report the generation of photon pairs by spontaneous FWM in photonic crystal fibre pumped by a 1.5 GHz repetition-rate vertical-external-cavity surface-emitting laser (VECSEL). The photon pairs exhibit high count rates and a coincidence-to-accidental ratio of over 80. The VECSEL's high repetition-rate, high average power, tunability, and small footprint make this an attractive source for quantum key distribution and photonic quantum-state engineering.Comment: 17 Pages, 5 Figure

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets. Intracranial ependymomas are segregated on the basis of anatomical location (supratentorial region or posterior fossa) and further divided into distinct molecular subgroups that reflect differences in the age of onset, gender predominance and response to therapy1,2,3. The most common and aggressive subgroup, posterior fossa ependymoma group A (PF-EPN-A), occurs in young children and appears to lack recurrent somatic mutations2. Conversely, posterior fossa ependymoma group B (PF-EPN-B) tumours display frequent large-scale copy number gains and losses but have favourable clinical outcomes1,3. More than 70% of supratentorial ependymomas are defined by highly recurrent gene fusions in the NF-κB subunit gene RELA (ST-EPN-RELA), and a smaller number involve fusion of the gene encoding the transcriptional activator YAP1 (ST-EPN-YAP1)1,3,4. Subependymomas, a distinct histologic variant, can also be found within the supratetorial and posterior fossa compartments, and account for the majority of tumours in the molecular subgroups ST-EPN-SE and PF-EPN-SE. Here we describe mapping of active chromatin landscapes in 42 primary ependymomas in two non-overlapping primary ependymoma cohorts, with the goal of identifying essential super-enhancer-associated genes on which tumour cells depend. Enhancer regions revealed putative oncogenes, molecular targets and pathways; inhibition of these targets with small molecule inhibitors or short hairpin RNA diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymomas. Through profiling of transcriptional enhancers, our study provides a framework for target and drug discovery in other cancers that lack known genetic drivers and are therefore difficult to treat.This work was supported by an Alex's Lemonade Stand Young Investigator Award (S.C.M.), The CIHR Banting Fellowship (S.C.M.), The Cancer Prevention Research Institute of Texas (S.C.M., RR170023), Sibylle Assmus Award for Neurooncology (K.W.P.), the DKFZ-MOST (Ministry of Science, Technology & Space, Israel) program in cancer research (H.W.), James S. McDonnell Foundation (J.N.R.) and NIH grants: CA154130 (J.N.R.), R01 CA169117 (J.N.R.), R01 CA171652 (J.N.R.), R01 NS087913 (J.N.R.) and R01 NS089272 (J.N.R.). R.C.G. is supported by NIH grants T32GM00725 and F30CA217065. M.D.T. is supported by The Garron Family Chair in Childhood Cancer Research, and grants from the Pediatric Brain Tumour Foundation, Grand Challenge Award from CureSearch for Children’s Cancer, the National Institutes of Health (R01CA148699, R01CA159859), The Terry Fox Research Institute and Brainchild. M.D.T. is also supported by a Stand Up To Cancer St. Baldrick’s Pediatric Dream Team Translational Research Grant (SU2C-AACR-DT1113)

Passively modelocked surface-emitting semiconductor lasers

This paper will review and discuss pico- and femtosecond pulse generation from passively modelocked vertical–external-cavity surface-emitting semiconductor lasers (VECSELs).We shall discuss the physical principles of ultrashort pulse generation in these lasers, considering in turn the role played by the semiconductor quantum well gain structure, and the saturable absorber. The paper will analyze the fundamental performance limits of these devices, and review the results that have been demonstrated to date. Different types of semiconductor saturable absorber mirror (SESAM) design, and their characteristic dynamics, are described in detail; exploring the ultimate goal of moving to a wafer integration approach, in which the SESAM is integrated into the VECSEL structure with tremendous gain in capability. In particular, the contrast between VECSELs and diode-pumped solid-state lasers and edge-emitting diode lasers will be discussed. Optically pumped VECSELs have led to an improvement by more than two orders of magnitude to date in the average output power achievable from a passively modelocked ultrafast semiconductor laser

Laser ions ring local modes first

We tend to think that lasers only produce light. In many solid-state lasers, however, just as much energy ends up as vibrations of the laser crystal as emerges in the laser beam. These vibrations are crucial to the operation of the laser because they carry excess energy away from the ion that produces laser emission. But we do not know how the ion transfers this energy into the lattice, in particular how each ion is able to release energies many times greater than those typical of thermal vibrations. Experiments by Dana Calistru and colleagues at City College in New York have now provided new insights into this mechanism that could lead to improved materials for solid-state lasers

Comment on SESAM-free mode-locked semiconductor disk laser

The authors of the recent paper titled “SESAM-free mode-locked semiconductor disk laser” [1] make the claim that Kerr lens mode-locking has been observed in a SESAM free semiconductor disk laser. However, the data presented in the manuscript at best weakly support the central claim that this laser is mode-locked and at worst are simply the characterisation of a continuous-wave (CW) laser. The physical principles of mode-locking are clearly defined in many text books as well as in the first paper reporting mode-locking [2] and more recently the work of H. A. Haus [3]. When reporting a new mode-locking technique for a particular class of laser, it is essential to pay detailed attention to the measured characteristics. It is also helpful to comment on the strength of the mode-locking mechanism. In this case, for example, the effective Kerr lens could be calculated, or better, experimentally measured, to further support the central claim

Supercontinuum generation with femtosecond pulse fiber amplified VECSELs

We present a mode-locked VECSEL emitting 400-fs pulses at a 3 GHz repetition rate at 1040 nm, amplified by a cascaded ytterbium doped fiber amplifier system to an average power of 40 W. The 3-ps duration amplified pulses are recompressed to their original 400-fs duration using a high-throughput transmission grating compressor. The recompressed pulses are used to generate supercontinuum with two different photonic crystal fibers (PCFs); an all-normal dispersion PCF and a PCF with a zero-dispersion wavelength at 1040 nm, creating spectra with 20 dB bandwidths of 200 nm with 3.9 W average power and 280 nm with 2.5 W average power respectively