Mean eGFR annual change (ml/min) among patients developing mild renal impairment during treatment with tenofovir.

<p>Results from the GEE multivariate linear model.</p

Characteristics of patients developing mild renal impairment under TDF.

<p>Characteristics of patients developing mild renal impairment under TDF.</p

Association between current TDF use and CKD, based on cumulative exposure to TDF after mild renal impairment occurrence.

<p>eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula.[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162320#pone.0162320.ref008" target="_blank">8</a>] Chronic Kidney Disease was defined as two eGFR <60 ml/min measured 3–6 months apart. Abbreviations: CI, confidence interval; CKD, chronic kidney disease; TDF, tenofovir disoproxil fumarate.</p