Microstructure and Mechanical Properties of Aluminum Cast Alloy A356 reinforced with Dual-Size B4C Particles

The paper details the studies carried out on a dual-size particulate composite prepared by stir casting using A 356 aluminum alloy and B4C powders. Three composite compositions, viz., A356 plus 2% B4C (44µm size and 105µm size in 1:1 ratio), 4% B4C (3:1 ratio), and 6% B4C (1:3 ratio) were cast in finger molds, from which test specimens were prepared for hardness and tensile tests as well as for metallography. Vickers hardness tests, tensile tests and microstructure analysis using an optical microscope were conducted. The results obtained indicated that the B4C particles were evenly distributed in the alloy matrix. EDS also revealed the presence of B4C in all the three composites.  In general, the hardness and tensile strengths increased with increase in concentration B4C powders. While the increase in hardness was increases less than 15%, there was significant increase (more than 35 %) in tensile strength. However, the ductility represented by % elongation, which was already very low in A 356 cast alloy (24.2%,), further decreased in composites. Tensile fractography results shows inter crystalline fracture where the breakage in the B4C particle instead of deboning were observed

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

OBJECTIVE—Two recent genome-wide association (GWA) studies have revealed novel loci for type 1 diabetes, a common multifactorial disease with a strong genetic component. To fully utilize the GWA data that we had obtained by genotyping 563 type 1 diabetes probands and 1,146 control subjects, as well as 483 case subject–parent trios, using the Illumina HumanHap550 BeadChip, we designed a full stage 2 study to capture other possible association signals

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians and African Americans (AA). Utilizing data from our ongoing GWA study in our cohort of 418 Caucasian obese children (BMI≥95th percentile), 2,270 Caucasian controls (BMI<95th percentile), 578 AA obese children and 1,424 AA controls, we investigated the association of the previously reported variation at the FTO locus with the childhood form of this disease in both ethnicities. The minor allele frequencies (MAF) of rs8050136 and rs3751812 (perfect surrogates for rs9939609 i.e. both r2 = 1) in the Caucasian cases were 0.448 and 0.443 respectively while they were 0.391 and 0.386 in Caucasian controls respectively, yielding for both an odds ratio (OR) of 1.27 (95% CI 1.08–1.47; P = 0.0022). Furthermore, the MAFs of rs8050136 and rs3751812 in the AA cases were 0.449 and 0.115 respectively while they were 0.436 and 0.090 in AA controls respectively, yielding an OR of 1.05 (95% CI 0.91–1.21; P = 0.49) and of 1.31 (95% CI 1.050–1.643; P = 0.017) respectively. Investigating all 13 SNPs present on the Illumina HumanHap550 BeadChip in this region of linkage disequilibrium, rs3751812 was the only SNP conferring significant risk in AA. We have therefore replicated and refined the association in an AA cohort and distilled a tag-SNP, rs3751812, which captures the ancestral origin of the actual mutation. As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact

The Effect of Heat treatment on Microstructure, Mechanical properties and Damping behaviour of hybrid composite of A356.0

ABSTRACT: In this study, Al-Si-Mg alloys A356.0 were stir cast by liquid metallurgy route with varied percentage of Alumina and Graphite. The composites were T6 treated and tested for microstructure and mechanical properties. Microstructure revealed uniform distribution of reinforcement in the matrix resulting in improved bonding of reinforcement in the matrix which in turn improved mechanical properties and Damping behaviour compared to un-reinforced material. The ceramic reinforced alloys were found to have improvement in Mechanical properties and Damping behaviour which may be attributed to the uniform distribution and bonding of reinforcement in the matrix