Blood monocytes, CD4+ and CD8+ T-cell count in 13 patients with pandemic H1N1 influenza and 13 healthy controls.

<p>Results are expressed in median (range).</p><p>Asterisks indicate significant decrease (p<0.05 versus controls).</p

Circulating myeloid dendritic cells (mDC) and plasmacytoid DC (pDC) in pandemic H1N1-infected patients and controls.

<p>Box plots show the 10th, 25th, 50th(median), 75th and 90th percentile and outlying values. Gray box plots represent the number of circulating mDCs (upper panel) and pDCs (lower panel) in 13 H1N1-infected patients at baseline (week 0) and during follow-up (week 1, 4 and 16). White box plots indicate 13 sex and aged-matched healthy controls. Asterisks indicate significant decrease of mDC and pDC (p<0,05 versus controls).</p

CD4+ and CD8+ T cell activation markers in pandemic H1N1-infected patients and controls.

<p>Box plots show the 10^th, 25^th, 50^th (median), 75^th and 90^th percentile and outlying values. Gray box plots represent the percentage of CD4+ T cells (upper panel) and CD8+ T cells (lower panel) that express activation markers CD38/HLA-DR in 13 H1N1-infected patients at baseline (week 0) and during follow-up (week 1, 4, and 16). White box plots indicate 13 sex and aged-matched healthy controls. Asterisks indicate a significant increase in percentage of double positive DR+/CD38+ in both CD4+ and CD8+ T cells (p<0,05 versus controls).</p

Plasma levels of chemokines and cytokines in pandemic H1N1-infected patients and controls.

<p>Dot plot represent circulating levels of chemokines CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES (upper panel) and cytokines TNF-α, IFN-α, IFN-γ, IP-10, IL-6, IL-15, IL-17 (lower panel) in 13 H1N1-infected patients at the time of hospitalization. Black circles indicate 13 sex and aged-matched healthy controls. Only the levels of IP-10 and RANTES were significantly higher in patients in comparison with the control group (p<0.01 for both).</p

Demographic and clinical characteristics of the 13 patients affected by pandemic H1N1 influenza.

<p>BMI: body mass index; Sat: saturation; CPAP: continuous positive airway pressure; COPD: chronic obstructive pulmonary disease.</p