37 research outputs found
Pyrrolidinium-Based Ionic Liquids as Sustainable Media in Heat-Transfer Processes
Ionic
liquids are viewed as green media for many engineering applications
and exhibit exceptional properties, including negligible vapor pressure, null
flammability, wide liquid range, and high thermal and chemical stabilities.
We present new thermophysical properties of 1-alkyl-1-methylpyrrolidinium
bis(trifluoromethylsulfonyl)imides ([C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] with <i>n</i> = 3, 4)
for future application them as heat-transfer media. The speed of sound
was measured at pressures up to 100 MPa and at temperatures from 293
K to 318 K. The <i>p</i>ρ<i>T</i>, <i>pC</i><sub><i>p</i></sub><i>T</i> data,
and derived thermophysical properties were determined using the acoustic
method. TGA of [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] and cytotoxicity of [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] and their imidazolium counterparts ([C<sub><i>n</i></sub>C<sub>1</sub>im][NTf<sub>2</sub>]) are investigated.
The physicochemical properties of [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] are compared with those of [C<sub><i>n</i></sub>C<sub>1</sub>im][NTf<sub>2</sub>] and commercial
heat-transfer fluids (Therminol VP-1, Therminol 66, Marlotherm SH).
[C<sub>3</sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] and [C<sub>4</sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] have a wide liquid range of ∼480
K and high decomposition onset temperatures of 771 and 776 K, respectively.
[C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>]
exhibit high energy storage density of ∼1.98 MJ m<sup>–3</sup> K<sup>–1</sup>, which is slightly dependent on temperature
and pressure. The thermal conductivity of [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] is comparable to that of
commercial heat-transfer fluids. [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] have lower toxicity for normal human
dermal fibroblast cells than [C<sub><i>n</i></sub>C<sub>1</sub>im][NTf<sub>2</sub>]. Thus, [C<sub><i>n</i></sub>C<sub>1</sub>pyr][NTf<sub>2</sub>] are promising heat-transfer fluid
candidates
Tubulin level (a) and PARP cleavage (b) in HCT-116 cells for 6b (0, 10, 20, 40 μM) and 17b (0, 10, 20, 40, μM).
<p>Tubulin level (a) and PARP cleavage (b) in HCT-116 cells for 6b (0, 10, 20, 40 μM) and 17b (0, 10, 20, 40, μM).</p
Quinolines and analogs with a marked anticancer activity.
<p>Quinolines and analogs with a marked anticancer activity.</p
Anti-cancer activity of the studied compounds (ND—not determined).
<p>Results are expressed as mean ± SD of at least three independent experiments. IC<sub>50</sub> values below 10 μM are bolded.</p><p>Anti-cancer activity of the studied compounds (ND—not determined).</p
Selective hydrolysis of styrylquinolines.
<p>For example, compare <b>2b</b>, <b>3b</b> and <b>18b</b>.</p
Synthesis of the compounds that were studied.
<p>Synthesis of the compounds that were studied.</p
Absorption spectra of 2c, 3c, 5b, 6b, CP-31398 and doxorubicin without CT-DNA (solid line) and with CT-DNA (dotted line).
<p>Absorption spectra of 2c, 3c, 5b, 6b, CP-31398 and doxorubicin without CT-DNA (solid line) and with CT-DNA (dotted line).</p
Activity (as—logIC<sub>50</sub>) vs logP of the compounds that were tested.
<p>Activity (as—logIC<sub>50</sub>) vs logP of the compounds that were tested.</p
Caspase-3/7 activities on the HCT116 cell lines.
<p>Caspase-3/7 activities on the HCT116 cell lines.</p
<i>In vitro</i> staining of HCT116 cells treated with 6b (CH I.) and MitoTracker Orange CMTMRos dye (CH II.).
<p><i>In vitro</i> staining of HCT116 cells treated with 6b (CH I.) and MitoTracker Orange CMTMRos dye (CH II.).</p