Association between 9 IL6 tagging SNPs (with P-value less than 0.05) and MD after adjustment for age and BMI, based on an additive genetic model (N = 301).

a<p>based on map to Genome Build 37.3.</p>b<p>Number of women with wild-wild genotype.</p>c<p>Number of women with wild-variant genotype.</p>d<p>Number of women with variant-variant genotype.</p>e<p>Minor allele frequency.</p>f<p>Percent MD per variant allele based on additive model adjusted for age at mammogram (continuous) and BMI at mammogram (continuous).</p

Association between 8 IL6 tagging SNPs from table 3 and MD in low and high BMI groups.

a<p>Percent MD per variant allele based on additive model adjusted for age at mammogram (continuous) and BMI at mammogram (continuous).</p>b<p>Number of women with wild-wild genotype.</p>c<p>Number of women with wild-variant genotype.</p>d<p>Number of women with variant-variant genotype.</p>e<p>P-value for interaction.</p

The association between the most significant SNP within each growth factor gene and MD in Norwegian women (N = 310).

a<p>Number of women with wild-wild genotype.</p>b<p>Number of women with wild-variant genotype.</p>c<p>Number of women with variant-variant genotype.</p>d<p>Minor allele frequency.</p>e<p>Percent MD per variant allele based on additive model adjusted for age at mammogram (continuous) and BMI at mammogram (continuous).</p

Associations between heartburn & regurgitation frequency, duration and esophageal adenocarcinoma and esophagogastric junction adenocarcinoma.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: CI, confidence interval.</p

Descriptors of Participants Eligible for Analysis of Heartburn/Regurgitation in Relation to Esophageal Adenocarcinoma and Esophagogastric Junction Adenocarcinoma.

<p>The median and interquartile range of each variable are provided, unless the variable is stated to be a percentage in which case the percentage and 95 percent confidence interval are provided. *This includes PPIs, H2RAs, antacids, and non-specific questions about anti-reflux medications/remedies. Abbreviations: EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; FINBAR, Factors Influencing the Barrett’s Adenocarcinoma Relationship (FINBAR) Study. 1Among those exposed.</p

Associations between recurrent heartburn and/or recurrent regurgitation and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p

Associations between heartburn and/or regurgitation frequency and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p

Forest plots of associations between heartburn and regurgitation exposures in relation to case and control groups in BEACON.

<p>A: The association between recurrent heartburn or recurrent regurgitation in relation to esophageal adenocarcinoma. B: The association between heartburn and regurgitation duration in relation to esophageal adenocarcinoma. C: The association between heartburn and regurgitation frequency in relation to esophageal adenocarcinoma. D. The frequency of recurrent heartburn or recurrent regurgitation exposure in case and control groups by study. For each plot each white square represents the study-specific odds ratio (A–C) or prevalence of exposure (D) and the black diamond represents the overall estimate. The arms of each symbol portray the 95% confidence intervals.</p

Associations between heartburn and/or regurgitation duration and adenocarcinomas of the esophagus.

<p>Adjusted for age, sex, BMI, education, alcohol consumption, cigarette smoking, and study-specific variables. Abbreviations: AA, all adenocarcinoma; CI, confidence interval; EA, esophageal adenocarcinoma; EGJA, esophagogastric junction adenocarcinoma; OR.</p

MiRNA-related SNPs and risk of EA.^#

<p>^#nominal P<0.05</p><p>^†Minor/major alleles</p><p>^<b>‡</b>Minor allele frequency</p><p>*OR adjusted for age, sex, PC1-PC4, using additive model (per-allele)</p><p>MiRNA-related SNPs and risk of EA.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128617#t002fn001" target="_blank">^#</a></p