Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction

This paper is about a way of correction of endothelial dysfunction with the inhibitor of arginase: L-norvaline. There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on the basis of endothelial dysfunction. Among vasodilatation agents, nitrogen oxide plays the basic role. Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an organism. Because of the high activity of arginase enzyme which catalyzes the hydrolysis of L-arginine into ornithine and urea, the bioavailability of nitrogen oxide decreases. The inhibitors of arginase suppress the activity of the given enzyme, raising and production of nitrogen oxide, preventing the development of endothelial dysfunction

Engineering and Technical Support of Territories for Implementation of Renovation Projects of the Housing Stock

This scientific article researches features of preparations for the construction of renovation projects areas on the example of the city of Moscow. The purpose of the article is to examine and study features of preparations for the construction of renovation projects areas, these feature’s being one of the factors determining energy efficiency activities application at a construction site. Statistical data compilation method, regulatory documents examination method and method of review, comparison and consolidation of information are used in this paper. In the context of the research engineering equipment provision of housing stock renovation sites is analysed and renovation areas classification based on water, heat and power supply system’s provision is provided. As a result of the analysis of five renovation areas, a number of specific features of renovation areas engineering equipment provision are identified. For the most part Moscow renovation areas are divided into two forms: energy-deficient (EP) which lack reserve margins of fuel and power resources; energy-excessive (ER) which have an excess supply of fuel and power resources. Energy-balanced areas (EB) are considered to be of the highest possible level of renovation areas development

Determining the Removal of Harmful Substances During the Construction Period

The construction industry is a fairly capacious consumer of various fuel and energy resources, the period of construction of buildings deserves special attention, which is comparable to the stage of operation in terms of average annual costs. A document containing maximum allowable emissions is mandatory for categories of enterprises, including construction industries, which, in the course of their work, pollute the atmosphere with emissions of various substances: combustion products, exhaust gases, dust, etc. The article assesses atmospheric air pollution with harmful substances from the operation of machines and mechanisms at the construction site during the construction of an apartment building. The values of harmful emissions by types of mechanization of construction works are considered. The maximum allowable total emissions into the atmosphere for the considered construction object were calculated in order to control the quality and composition of pollutants into the atmosphere from mechanized sources located at the construction site. The results of calculations of maximum allowable emissions make it possible to assess the level of impact on the atmospheric air. If the emission values are exceeded, monitoring of compliance with environmental pollution is introduced in order to take corrective measures to improve the environmental situation

Calculation of Fuel and Energy Resource Consumption during Building Demolition

Currently, megalopolises and large cities are characterized by the processes of renovation of existing residential buildings of previous periods of construction, as a rule of lower number of storeys. The issue of energy consumption during the renovation of buildings in dense urban areas is complex and systemic in nature and covers all stages of the life cycle of the development of residential areas due to the fact that the existing residential development is interconnected with the existing system of engineering networks and communications. In this regard, construction production in the process of demolition of old buildings and construction of new apartment buildings is of a specific nature, which should involve rationing and regulation of the consumption of fuel and energy resources. The article discusses the features of work at the demolition stage in the process of renovation of residential buildings, taking into account the consumption of fuel and energy resources by the main consumers - means of mechanization. Using the example of a five-story panel residential building, the total energy consumption during demolition by mechanical collapse and element-by-element disassembly with the preservation of suitable materials was determined, and the relationship between these two options was established

Indigenous Peoples and local communities report ongoing and widespread climate change impacts on local social-ecological systems

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