Additional file 1: Table S1. of Urine proteomics in the diagnosis of stable angina

Cohort characteristics of patients with severe CAD planned to undergo CABG surgery and age matched healthy volunteers. Table S2. Cohort characteristics of combined patients with CAD and controls (NCA or healthy volunteers). Figure S1. Flowchart of the DiCADu study design and recruitment process. CAD, coronary artery disease; NCA, normal coronary arteries. Figure S2. Effect of drug treatment on the CAD238 score. For comparisons Student’s t-test was used. ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; BB, beta-blocker. Figure S3. Correlation between age and CAD238 score in control subjects. The Pearson correlation coefficient and the corresponding P-value are shown. Figure S4. Comparison of CAD238 score between patients with NCA and CAD corrected for remaining coronary atherosclerosis after percutaneous coronary intervention. Lines represent the median. NCA, normal coronary arteries. (DOC 1181 kb

Additional file 3: of Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Video S1. (Quicktime) Video to illustrate the DORV phenotype finding in an Adamts6 mutant heart. (MOV 1983 kb

Additional file 2: of Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Figure S1. Manhattan plot for European and African-American ancestry single variant analysis. Figure S2. Quantile-quantile plot for European and African-American ancestry single variant analysis. Figure S3. Manhattan plot for EA single variant analysis. Figure S4. QQ plot for EA single variant analysis. Figure S5. Manhattan plot for AA single variant analysis. Figure S6. Quantile-quantile plot for AA single variant analysis. Figure S7. Miami plot European and African-American ancestry sex-stratified single variant analysis. Figure S8. Quantile-quantile plots for European and African-American ancestry sex-stratified single variant analyses. Figure S9. Normal morphology of adult Adamts6 heterozygous hearts. (DOCX 4290 kb