The processing of color preference in the brain

Decades of research has established that humans have preferences for some colors (e.g., blue) and a dislike of others (e.g., dark chartreuse), with preference varying systematically with variation in hue (e.g., Hurlbert & Owen, 2015). Here, we used functional MRI to investigate why humans have likes and dislikes for simple patches of color, and to understand the neural basis of preference, aesthetics and value judgements more generally. We looked for correlations of a behavioural measure of color preference with the blood oxygen level-dependent (BOLD) response when participants performed an irrelevant orientation judgement task on colored squares. A whole brain analysis found a significant correlation between BOLD activity and color preference in the posterior midline cortex (PMC), centred on the precuneus but extending into the adjacent posterior cingulate and cuneus. These results demonstrate that brain activity is modulated by color preference, even when such preferences are irrelevant to the ongoing task the participants are engaged. They also suggest that color preferences automatically influence our processing of the visual world. Interestingly, the effect in the PMC overlaps with regions identified in neuroimaging studies of preference and value judgements of other types of stimuli. Therefore, our findings extends this literature to show that the PMC is related to automatic encoding of subjective value even for basic visual features such as color

Establishing SME–university collaboration through innovation support programmes

Purpose – The research purpose is to analyse when and how innovation support programmes (ISPs) can affectcollaboration between universities and established small and medium sized enterprises (SMEs). The paperspecifically considers SME’s absorptive capacity.Design/methodology/approach – A Swedish research centre is studied in the context of innovation supportand two of its SME-ISPs are examined with regards to industry–university collaboration and impact on firminnovation capabilities. Data collection and analysis are performed, using interviews, survey answers,document search and reflectional analysis to evaluate processes and effects of the centre and the programmes.Findings – A developed research centre, integrated into both academia and industry, can supporttranslational collaboration and promote SME innovation absorptive capacity. The action learning elementsand the organisational development approaches used when coaching in the ISPs contribute to the SMEsinternal absorption capacity and collaborational skills. Organising collaboration into ISPs can provide arelational path to future collaboration with universities, which, for example start with student projects.Research limitations/implications – The study, though limited to one Swedish region, adds to empiricalinnovation research as it connects industry–university collaboration and absorptive capacity to organisationallearning.Practical implications – The empirical results indicate possible long-term gains for industry anduniversities in building collaborative innovation into SME-ISPs.Originality/value – The contribution of this study pertains to the practice of innovation support forestablished SMEs with the inclusion of absorption capacity and collaborative innovation development

Caledonian and Pre-Caledonian orogenic events in Shetland, Scotland:evidence from garnet Lu-Hf and Sm-Nd geochronology

Garnet Lu-Hf and Sm-Nd ages from the Shetland Caledonides provide evidence of a pollorogenic history as follows: 1) c. 1050 Ma Grenvillian reworking of Neoarchaean basement; 2) c. 910 Ma Renlandian metamorphism of the Westing Group; 3) c. 622-606 Ma metamorphism of the Walls Metamorphic Series but of uncertain significance because the eastern margin of Laurentia is thought to have been in extension at that time; 4) Grampian I ophiolite obduction at c. 491 Ma followed by crustal thickening and metamorphism between c. 485 and c. 466 Ma; 5) Grampian II metamorphism between c. 458 and c. 442 Ma that appears to have been focused in areas here pre-existing foliations ere gentle-inclined and thus may have been relatively easily reworked; 6) Scandian metamorphism at c. 430 Ma, although the paucity of these ages suggests that much of Shetland did not attain temperatures for garnet growth. There is no significant difference in the timing of Caledonian orogenic events either side of the Walls Boundary Fault, although this need not preclude linkage with the Great Glen Fault. However, the incompatibility of Ediacaran events either side of the Walls Boundary Fault may indicate significant lateral displacement and requires further investigation

The Bristol Twenty Miles Per Hour Limit Evaluation (BRITE) Study

This study aimed to evaluate the impact of the roll-out of 20mph speed limits across the city of Bristol. The research took a holistic, public health approach to evaluation, using a variety of data sources to examine changes in vehicle speeds, road traffic casualties, levels of walking and cycling, public perceptions and attitudes, and reported levels of health and wellbeing across the city. The study found statistically significant reductions in average traffic speeds of 2.7mph across the city of Bristol, following the introduction of 20mph speed limits. This is a larger reduction than seen in previous evaluations in other cities. The study employed a more sophisticated analysis than previous studies of 20mph limits, including using individual speed data from over 36 million vehicle observations and controlling for other factors that might affect changes in traffic speeds. There has been a reduction in the number of fatal, serious and slight injuries from road traffic collisions, equating to estimated cost savings of over £15 million per year. Although there is still majority support for 20mph speed limits in Bristol, there remains concern about compliance and behaviour of other drivers. Walking and cycling across Bristol has increased, both among children travelling to school and adults travelling to work. The introduction of 20mph speed limits in Bristol offers a model for other towns and cities across the UK, who are seeking to reduce traffic speeds, cut road traffic casualties, and promote community health and wellbeing through road danger reduction. In order to assess effectiveness of 20mph speed limits, it is vital that other towns and cities follow Bristol’s example, and prioritise the ongoing collection and analysis of appropriate data on vehicle speeds, road traffic casualties and wider public health impacts

Supplemental prophylactic intervention for chemotherapy-induced nausea and emesis (spice) trial: Protocol for a multi-centre double-blind placebo-controlled randomized trial

Aim: There is significant recent interest in the role of ginger root (Zingiber officinale) as an adjuvant therapy for chemotherapy‐induced nausea. The supplemental prophylactic intervention for chemotherapy‐induced nausea and emesis (SPICE) trial aims to assess the efficacy by reduced incidence and severity of chemotherapy‐induced nausea and vomiting, and enhanced quality of life, safety and cost effectiveness of a standardised adjuvant ginger root supplement in adults undergoing single‐day moderate‐to‐highly emetogenic chemotherapy. Methods: Multisite, double‐blind, placebo‐controlled randomised trial with two parallel arms and 1:1 allocation. The target sample size is n = 300. The intervention comprises four capsules of ginger root (totalling 60 mg of active gingerols/day), commencing the day of chemotherapy and continuing for five days during chemotherapy cycles 1 to 3. The primary outcome is chemotherapy‐induced nausea‐related quality of life. Secondary outcomes include nutrition status; anticipatory, acute and delayed nausea and vomiting; fatigue; depression and anxiety; global quality of life; health service use and costs; adverse events; and adherence. Results: During the five‐month recruitment period from October 2017 to April 2018 at site A only, a total of n = 33 participants (n = 18 female) have been enrolled in the SPICE trial. Recruitment is expected to commence at Site B in May 2018. Conclusions: The trial is designed to meet research gaps and could provide evidence to recommend specific dosing regimens as an adjuvant for chemotherapy‐induced nausea and vomiting prevention and management.No Full Tex

Categorified quantum sl(2) is an inverse limit of flag 2-categories

We prove that categorified quantum sl(2) is an inverse limit of Flag 2-categories defined using cohomology rings of iterated flag varieties. This inverse limit is an instance of a 2-limit in a bicategory giving rise to a universal property that characterizes the categorification of quantum sl(2) uniquely up to equivalence. As an application we characterize all bimodule homomorphisms in the Flag 2-category and prove that the categorified quantum Casimir of sl(2) acts appropriately on these 2-representations.Comment: 21 pages, with xypic diagrams. v2 corrects typo

Fully Dried Two-Dimensional Paper Network for Enzymatically Enhanced Detection of Nucleic Acid Amplicons

Two-dimensional paper networks (2DPNs) have enabled the use of paper-based platforms to perform multistep immunoassays for detection of pathogenic diseases at the point-of-care. To date, however, detection has required the user to provide multiple signal enhancement solutions and been limited to protein targets. We solve these challenges by using mathematical equations to guide the device design of a novel 2DPN, which leverages multiple fluidic inputs to apply fully dried solutions of hydrogen peroxide, diaminobenzidine, and horseradish peroxidase signal enhancement reagents to enhance the limit-ofdetection of numerous nucleic acid products. Upon rehydration in our unique 2DPN design, the dried signal enhancement solution reduces the limit-of-detection (LOD) of the device to 5 × 1011 nucleic acid copies/mL without increasing false positive detection. Our easy-to-use device retains activity after 28 days of dry storage and produces reliable signal enhancement 40 min after sample application. The fully integrated device demonstrated versatility in its ability to detect double-stranded and single-stranded DNA samples, as well as peptide nucleic acids

Diatom Abundance and Diversity Across the Arcata Wastewater Treatment Plant and Wildlife Sanctuary

Wastewater management is an essential component of modern society that is necessary for reducing human environmental impact, particularly in aquatic ecosystems. In Humboldt County, California, the Arcata Wastewater Treatment Plant and Wildlife Sanctuary (Arcata Marsh) is a model for other wastewater treatment plants worldwide to treat waste naturally, reducing the use of chemicals. This wastewater is then discharged into the Humboldt Bay. It is well known how treatment helps remove harmful waste materials, but it has not been investigated how phytoplankton diversity is affected before, during, and after treatment. Phytoplankton are primary producers that are responsible for carbon sequestration and production of oxygen, and are an essential food source for higher trophic-level organisms. When nutrient levels are high, such as in human waste water, it can lead to single species proliferation, thus resulting in lower diversity and higher abundance of other species in the community. This can have negative consequences on the higher trophic levels that consume them and also creates “dead-zones\u27\u27 where aerobic species are unable to survive. In this study, pre-treatment water and post-treatment water were sampled and observed for diversity and abundance of diatoms, a quantifiable subphylum of phytoplankton. It was hypothesized that successful treatment would result in higher diversity of diatoms in post-treatment waters than that of pretreatment waters. This study found 30 morphologies across all sample sites, with abundance of 2-4 species being significantly greater in pre-treatment ponds than post-treatment ponds. There were no significant trends in diversity across the ponds