1 research outputs found
Effects of Stigmasterol and β‑Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis
To study the effects
of stigmasterol and β-sitosterol on
high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease
(NAFLD), lipidomic analyses were conducted in liver samples collected
after 33 weeks of the treatment. Principal component analysis showed
these phytosterols were effective in protecting against HFWD-induced
NAFLD. Orthogonal projections to latent structures–discriminate
analysis (OPLS-DA) and S-plots showed that triacylglycerols (TGs),
phosphatidylcholines, cholesteryl esters, diacylglycerols, and free
fatty acids (FFAs) were the major lipid species contributing to these
discriminations. The alleviation of NAFLD is mainly associated with
decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids,
and alterations of free hepatic FFA. In conclusion, phytosterols,
at a dose comparable to that suggested for humans by the FDA for the
reduction of plasma cholesterol levels, are shown to protect against
NAFLD in this long-term (33-week) study