1 research outputs found
Cu(I)/<i>N,N</i>-Imine Ligand Catalyzed C(sp<sup>3</sup>)–C(sp) Coupling of Alkyl Bromides with Alkynes: Scope and Mechanistic Investigation
We
have developed an efficient Cu/N,N-bidentate imine ligand catalytic system for C(sp3)–C(sp)
coupling to obtain internal alkynes, di/trisubstituted allenes and
strained bridged cyclic lactams in moderate to excellent yields from
readily available alkyl(benzyl) bromides in one-pot transformation.
Density Functional Theory (DFT) assisted mechanistic study along with
control experiments support the involvement of bialkynylated copper
species which undergo single electron transfer (SET) with alkyl halides
to generate radical intermediate in the reaction. The N,N-bidentate imine ligand plays a vital role in
stabilization of intermediate copper complex and facilitates the product
formation