3 research outputs found
The role of indole derivative in the growth of plants: A review
Indole compounds with their unique properties of mimicking peptide structures and reversible binding to enzymes are of great exploitative value in the regulation of plant growth. They stimulate root and fruit formation and activate the plant’s immune system against biotic and abiotic factors harmful to the plant. Analysis of target recognition, receptor recognition, key activation sites and activation mechanisms of indoles in plant to enhance crop growth or disease resistance is a crucial step for further developing compounds as plant growth regulators and immune inducers. Therefore, this review focused on the mechanism of action of indoles in regulating plant growth and enhancing plant resistance to biotic and abiotic stresses
Design, Synthesis, and Bioactivity of Spiro Derivatives Containing a Pyridine Moiety
We designed and synthesized a series of pyridine spiro
derivatives
and evaluated their insecticidal and antiviral activities. Some compounds
exhibited good insecticidal and antiviral activities. Notably, the E series of compounds displayed good insecticidal activity
against Tetranychus urticae. Compounds E20 (EC50 = 63.68 mg/L) and F4 (EC50 = 47.81 mg/L) exhibited inactivation activities against the tobacco
mosaic virus (TMV), which were similar to that of Ningnanmycin (EC50 = 58.01 mg/L). Molecular docking showed that compounds E20 and F4 exhibited satisfactory affinities
for the TMV coat protein (TMV-CP), with binding energies (−6.7
and −6.4 kcal/mol, respectively) slightly lower than that of
Ningnanmycin (−6.3 kcal/mol). Further, molecular dynamics analysis
revealed that compounds E20 and F4 exhibited
better binding stability values than Ningnanmycin. Microscale thermophoresis
showed that compounds E20 (Kd = 0.053 ± 0.016 μM) and F4 (Kd = 0.045 ± 0.022 μM) bound more strongly to
TMV-CP than Ningnanmycin (Kd = 0.10 ±
0.029 μM). The results of transmission electron microscopy showed
that these two compounds hindered the self-assembly and growth of
TMV. In summary, we showed that these pyridine spiro derivatives could
be used as a basis for the research and development of novel pesticides