1 research outputs found
3‑Methoxyazetidin-2-one Functionalized CuO–CB Microfibrils: A Drug Formulation with Controlled Release and Enhanced Synergistic Antibacterial Activities
trans-1-(4′-Methoxyphenyl)-3-methoxy-4-phenyl
3-methoxyazetidin-2-one (or 3-methoxyazetidin-2-one) is one of the
important β-lactam derivatives with an ample range of bacterial
activities yet few restrictions. To enhance the competency of the
chosen 3-methoxyazetidin-2-one, microfibrils composed of copper oxide
(CuO) and filter scraps of cigarette butts (CB) were chosen in the
current work for developing a potential release formulation. The preparation
of CuO-CB microfibrils required a simple reflux technique and a subsequent
calcination treatment. The loading of 3-methoxyazetidin-2-one was
processed via controlled magnetic stirring followed by centrifugation
with microfibrils of CuO-CB. To confirm the loading efficiency, the
3-methoxyazetidin-2-one@CuO-CB complex was analyzed by scanning electron
microscopy, transmission electron microscopy, and infrared spectroscopy.
Compared to the CuO nanoparticles, the release profile of CuO-CB microfibrils
indicates only 32% of the drug release in the first 1 h at pH 7.4.
As a model organism, E. coli has been utilized for in vitro drug release dynamic studies. Based on the observed
drug release data, it was found that the prepared formulation evades
premature drug release and triggers the on-demand release of drug
inside bacterial cells. The controlled drug release by 3-methoxyazetidin-2-one@CuO-CB
microfibrils over a period of 12 h further ascertained the excellent
bactericide delivery mechanism to combat deadly bacterial resistance.
Indeed, this study provides a strategy to combat antimicrobial resistance
and eradicate bacterial disease via nanotherapeutics