3 research outputs found
Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1-hydroxylation
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No full textAbbreviations: CYP, cytochrome P450; rCYP3A4, recombinant human cytochrome P450 3A4; rCYP3A5, recombinant human cytochrome P450 3A5; HLMs, human liver microsomes; NADPH-CYP reductase, NADPH-cytochrome P450 reductase; K m , substrate concentration at half-maximal product formation rate; LC/MS/MS, liquid chromatography-tandem mass spectrometry; V max , maximal product formation rate
