1 research outputs found
Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in <i>Streptococcus mutans</i> Biofilms
The
oral microbiome is a dynamic environment inhabited by both commensals
and pathogens. Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent childhood
disease. Carolacton has remarkably specific activity against S. mutans, causing acid-mediated cell death during
biofilm formation; however, its complex structure limits its utility.
Herein, we report the diverted total synthesis and biological evaluation
of a rationally designed library of simplified analogs that unveiled
three unique biofilm phenotypes further validating the role of natural
product synthesis in the discovery of new biological phenomena