Computer Interfaces to Organizations: Perspectives on Borg-Human Interaction Design

We use the term borg to refer to the complex organizations composed of people, machines, and processes with which users frequently interact using computer interfaces and websites. Unlike interfaces to pure machines, we contend that borg-human interaction (BHI) happens in a context combining the anthropomorphization of the interface, conflict with users, and dramatization of the interaction process. We believe this context requires designers to construct the human facet of the borg, a structure encompassing the borg's personality, social behavior, and embodied actions; and the strategies to co-create dramatic narratives with the user. To design the human facet of a borg, different concepts and models are explored and discussed, borrowing ideas from psychology, sociology, and arts. Based on those foundations, we propose six design methodologies to complement traditional computer-human interface design techniques, including play-and-freeze enactment of conflicts and the use of giant puppets as interface prototypes.Comment: 10 page

Additional file 6: of A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Novel candidate conserved homologs associated with genes sets. Sheet 1: results using tissue gene sets. Sheet 2: results using pathway gene sets. Sheet 3: results using disease gene sets. Sheets 4, 5 and 6: Same analysis as sheet 1, 2 and 3 but using one-to-one homologous genes only. (XLS 11362 kb

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people-0

D8+ T cells were subdivided into the main T cell subsets using CD45RA and CCR7. (C) The CD45RA+CCR7+ N, CD45RA-CCR7+ CM, CD45-CCR7- EM and CD45RA+ CCR7- TEMRA CD8+ T cells were plotted against CD27 and CD28. According to the subset model (Figure 1) the different CD27 and CD28 dependent subpopulations (D) CM, (E) N, (F) EM and (G) TEMRA subsets were analyzed for CD57 and KLRG1.<p><b>Copyright information:</b></p><p>Taken from "Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people"</p><p>http://www.immunityageing.com/content/5/1/6</p><p>Immunity & Ageing : I & A 2008;5():6-6.</p><p>Published online 25 Jul 2008</p><p>PMCID:PMC2515281.</p><p></p

Additional file 5: of A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Evolutionary changes of gene sets described by the four parameters of conservation explained in the manuscript. Sheet 1: results using tissue gene sets. Sheet 2: results using pathway gene sets. Sheet 3: results using disease gene sets. (XLS 552 kb

Correlation between tri-functional CD8+ T cells and CD57 expression in the individuals studied (n = 32).

<p>Y axis represents the percentage of CD8+ T cells that express CD57. X axis represents the percentage of tri-functional CD8+ T cells.</p

CD8+CD57+ T cell frequency and functionality in healthy individuals.

<p>A) CD57 expression in CD8+ T cells of healthy individuals stratified by CMV serostatus and age. B) Three-function analysis of SEB responses of CD8+CD57– and CD8+CD57+ T cell subsets. Scatter graphs show the magnitude of SEB responses in each functional category, expressed as percentage of CD8+CD57- T cells or CD8+CD57+ T cells. Vertical black lines indicate interquartile ranges, ranging from the 25th to the 75th percentile. The median response for each category is indicated by a horizontal black line. The combination of functions studied is indicated in the table below the scatter graphs.</p

CD8+ T cells' responses to SEB stimulation, in healthy individuals stratified by CMV serostatus and age.

<p>A) Percentage of CD3+CD8+ T cells that have any studied response to SEB. B) Total degranulation (CD107a) and cytokine production (IFN-gamma, TNF-alpha) by CD3+CD8+ T lymphocytes responding to SEB. Vertical black lines indicate interquartile ranges, ranging from the 25th to the 75th percentile. The median response for each category is indicated by a horizontal black line. C) Three-function analysis of SEB responses. Scatter graphs show the magnitude of SEB responses in each functional category, expressed as percentage of CD3+CD8+ T cells. The combination of functions studied is indicated in the table below the scatter graphs.</p

Chemokine receptor expression on T-cell subsets.

<p>Expression of the chemokine receptors CCR4 (on Th2 cells), CCR5 (on differentiated Th1 cells) and CCR6 (mostly on non activate memory cells and Th17 cells) on CD4+ (left-hand panels) and CD8+ T-cells (right-hand panels) in AD patients (diamonds) and healthy controls (circles) with medians and p values obtained by Mann Whitney analysis using Graphpad Prism.</p

T-cell subsets.

<p>Percentages of CD4+ (A) and CD8+ (B) T-cell subsets. After selecting living single CD3+ T-cells, the populations of CD4+ and CD8+ cells were gated. The values of 23 AD patients are displayed in diamonds and compared to those of 10 healthy controls in circles.</p

Naïve and memory CD4+ T-cells.

<p>Percentages of early-differentiated CD4+ T-cells in A (CD27+CD28+) and C (CD27+CD28+CD45RA+CD45RO-); percentages of late-differentiated T-cells in B (CD27-CD28-) and D (CD27-CD28-CD45RO+). For statistical analysis Mann Whitney test was applied and resulting p values are displayed.</p