6 research outputs found
Redox-Neutral Aromatization of Cyclic Amines: Mechanistic Insights and Harnessing of Reactive Intermediates for Amine alpha- and beta-C-H Functionalization
Cyclic amines such as pyrrolidine and piperidine are known to undergo condensations with aldehydes to furnish pyrrole and pyridine derivatives, respectively. A combined experimental and computational study provides detailed insights into the mechanism of pyrrole formation. A number of reactive intermediates (e.g., azomethine ylides, conjugated azomethine ylides, enamines) were intercepted, outlining strategies for circumventing aromatization as a valuable pathway for amine C-H functionalization
Decarboxylative Annulation of α‑Amino Acids with β‑Ketoaldehydes
Indolizidine
and quinolizidine derivatives are readily assembled
from l-proline or (±)-pipecolic acid and β-ketoaldehydes
via a decarboxylative annulation process. These reactions are promoted
by acetic acid and involve azomethine ylides as reactive intermediates