PREPARATION AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES ON DISACCHARIDE TEMPLATES

We report here the preparation of nanoparticles of iron oxide in the presence of polysaccharidetemplates. Interaction between iron sulfate and template has been carried out in aqueous phase,followed by the selective and controlled removal of the template to achieve narrow distribution ofparticle size. Particles of iron oxide obtained have been characterized for their stability in solventmedia, size, size distribution and crystallinity and it was found that when the negative value of thezeta potential increases, particle size decreases. A narrow particle size distribution with D100 = 275nm was obtained with chitosan and starch templates. SEM measurements further confirm the particlesize measurement. Diffuse reflectance UV–VIS spectra values show that the template is completelyremoved from the final iron oxide particles and powder XRD measurements show that the peaks ofthe diffractogram are in agreement with the theoretical data of hematite. The salient observations ofour study shows that there occurs a direct correlation between zeta potential, polydispersity index,band gap energy and particle size. The crystallite size of the particles was found to be 30–35 nm. Alarge negative zeta potential was found to be advantageous for achieving lower particle sizes, as theparticles remained discrete without agglomeration

IN VITRO CHARACTERZATIOAN AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM FOR METOPROLOL TARTARATE

Transdermal delivery system bypass the hepatic first pass metabolism and avoid drug degradation due to gastrointestinal pH, enzymes etc., minimize plasma level fluctuations and extend the drug activity besides improving patient compliance. Transdermal films of metoprolol tartarate were prepared using polymers such as ethyl cellulose, poly vinyl alcohol, eudragit RL100, eudragit L100. Di-n-butylphlthalate was used as plasticizer. The study was undertaken to report the film forming properties of polymers used and in vitro drug release from the prepared monolithic matrices. Effect of drug loading on the drug release rate was also studied. The transdermal films were prepared using solvent casting method. These films were evaluated for Thickness, Percent moisture loss, Percent moisture absorption, Drug content, Weight variation and folding endurance. In-vitro drug release kinetics was studied using Franz-diffusion cell. Drug release followed zero order kinetics. Drug loading at different concentrations found to have less effect on the film forming properties of the constituent polymers. Results have shown enhanced flux per unit time across rat skin. In conclusion combination of ethyl cellulose, poly vinyl alcohol, eudragit RL100, eudragit L100 and Di-n-butylphlthalate can potentially be optimized to develop an effective transdermal drug delivery system for metoprolol tartarat