(A-D): Univariate and multivariate analyses used to identify predictors of each cognitive composite z score.

<p>(A-D): Univariate and multivariate analyses used to identify predictors of each cognitive composite z score.</p

Clinical characteristics in young, old healthy controls and CHD patients.

<p>Clinical characteristics in young, old healthy controls and CHD patients.</p

Cognitive function parameters in young, old healthy controls and CHD patients.

<p>Cognitive function parameters in young, old healthy controls and CHD patients.</p

Cardiopulmonary exercise testing data in young, old healthy controls and CHD patients.

<p>Cardiopulmonary exercise testing data in young, old healthy controls and CHD patients.</p

Flowchart of the inclusion of the subjects.

<p>Flowchart of the inclusion of the subjects.</p

(a-d): Brain NIRS parameters during recovery in young (YC), old healthy controls (OC) and CHD patients (CHD).

<p>Post hoc for group effect = a: young vs. old, b = young vs. CHD, c = old vs. CHD, * = P<0.05, † = P<0.01, ‡ = P<0.001, § = P<0.0001.</p

(a-d): Brain NIRS parameters during exercise in young (YC), old healthy controls (OC) and CHD patients (CHD).

<p>Post hoc for group effect = a: young vs. old, b = young vs. CHD, * = P<0.05, † = P<0.01, ‡ = P<0.001, § = P<0.0001.</p

Flowchart illustrating the "n" values between groups throughout the study.

<p>Flowchart illustrating the "n" values between groups throughout the study.</p

Flowchart illustrating the "n" values between groups throughout the study.

<p>Flowchart illustrating the "n" values between groups throughout the study.</p

Detectable <i>ANGPTL2</i> methylation profile.

<p>Quantification of various methylation sites located in the <i>ANGPTL2</i> gene identified following a preliminary genome-wide exploratory assay. DNA samples were pooled from a small number of participants taken from all three groups. Data are mean ± SEM of a total of 16 patients from the young controls (n = 4), age-matched controls (n = 7) and post-ACS patients (n = 5).</p