An alum [KAl (SO4)2.12H2O] catalyzed microwave assisted multicomponent synthesis of bioactive functionalized benzylpyrazolyl coumarin and quinolinone derivatives in PEG

An efficient and environmentally benign method has been developed for the synthesis of benzylpyrazolyl coumarin and quinolinone derivatives, hydroxy coumarin derivatives using Alum [KAl (SO4)2.12H2O] catalyst and Polyethylene glycol as green solvent under microwave condition. Keywords: Knoevenagel, Michael addition reaction, coumarins, quinolinones, alum, polyethylene glycol, multicomponent microwave irradiation method

Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-<i>a</i>]pyridines and 2-phenylimidazo[1,2-<i>a</i>]quinoline in water–PEG-400

<p>An effective, expeditious, environmentally benign one-pot synthesis of 2-phenylimidazo[1,2-<i>a</i>]pyridines and 2-phenylimidazo[1,2-<i>a</i>]quinoline from easily available starting materials as aromatic carbonyl compound, 2-amino pyridine, succinamide, and <i>in situ</i> generated α-iodo acetophenone in combination with green solvent PEG-400 and water (2:1) under microwave irradiation. The newly developed protocol with excellent yield of product in very short time of reaction by avoiding the use of lachrymatric α-chloro and α-bromocarbonyl compounds, volatile, toxic organic and hazardous solvents, reagents is the advantage of this research work. The final products were confirmed by their characterization data such as ¹H NMR, ¹³C NMR, high resolution mass spectrometry (HRMS) and were compared with its reported method.</p