The distribution of GDV similarity of protein pairs in the human PPI network.

<p>Horizontal axis represents GDV-similarities of node pairs in the network in bins of . Vertical axis represents percentages of protein pairs that have a particular GDV-similarity.</p

Predicted CVD genes.

<p>The first two columns: predicted CVD genes (Entrez Gene IDs and Official Gene Symbols respectively). The third column: GO terms that the genes are annotated with. We only take into consideration GO terms in which this set of 17 genes is statistically significantly enriched. We only list GO terms that correspond to biological functions that the three drug mechanisms of interest rely on. BP denotes “biological process,” while MF denotes “molecular function” of GO. The fourth column: if we validate that the predicted gene is associated with a CVD, we give the PubMed ID of the corresponding reference; “–”means that we found no literature validation.</p

Summary of the results.

<p>The Core Diseasome of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071537#pone.0071537-Janji1" target="_blank">[22]</a> is overlaid with the results of this study. Green nodes are the Key CVD Genes (from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071537#pone-0071537-t001" target="_blank">Table 1</a>), which are in the Core Diseasome. Blue nodes are predicted CVD genes (from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071537#pone-0071537-t002" target="_blank">Table 2</a>) that we validated in the literature and that are in the Core Diseasome. Red nodes are non-validated CVD gene predictions (from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071537#pone-0071537-t002" target="_blank">Table 2</a>) that are in the Core Diseasome. Triangular nodes are drug targets. Driver genes are bordered in red.</p

The Key Cardiovascular Disease Genes that are known drug targets.

<p>The first column: Entrez Gene ID. The second column: Official Gene Symbol. The third column: the number of drugs from Drugbank that target the corresponding gene.</p

The Ten Key Cardiovascular Disease Genes.

<p>The first two columns: ten Key CVD genes (Entrez Gene IDs and Official Gene Symbols respectively). The third column: GO terms that the genes are annotated with. We only take into consideration GO terms in which this set of 10 genes is statistically significantly enriched. We only list GO terms that correspond to biological functions that the three drug mechanisms of interest rely on. BP denotes “biological process,” while MF denotes “molecular function” of GO. The fourth column: CVDs that the genes are associated with.</p