Guía itinerario formativo pregrado y postgrado servicio: Medicina Interna. INT-XXIPS_MIN_01_2021

Guía del itinerario formativo de los residentes en el servicio de Medicina Interna del Complejo Hospitalario Universitario de Pontevedra.Guía do itinerario formativo dos residentes no servizo de Medicina Interna do Complexo Hospitalario Universitario de Pontevedra

Relationship between thyroid dysfunction and body weight: A not so evident paradigm

Purpose: Hypothyroidism has traditionally been associated with obesity, whereas hyperthyroidism has been linked to being underweight. However, very few studies have assessed these associations. The aim of this work is to evaluate the association between thyroid dysfunction and body mass index (BMI) at baseline and after normalization of the hormone levels. Patients and methods: A retrospective, observational study of a cohort of otherwise healthy patients that were referred for evaluation of thyroid dysfunction to the Endocrine Department of Pontevedra University Complex Hospital, Spain was conducted. We collected data of BMI and thyroid hormone levels before treatment and after normalization of thyroid function within a follow-up period of 12 months. Results: A total of 330 patients were initially selected for the study. In order to exclude variables that for any reason could influence on BMI, 235 were excluded for further studies. Another 61 patients were also excluded because incomplete data on their medical records, failure to achieve euthyroidism, or lost to follow-up. Therefore, the eligible final study group consisted of 34 patients (17 with hypothyroidism and 17 with hyperthyroidism). No differences were observed in mean baseline BMI between hypo and hyperthyroid patients (27.07+/-3.22 vs 26.39+/-4.44, p=0.609). Overweight or obesity was observed in 76.5% and 58.8% of hypothyroid and hyperthyroid patients, respectively (p=0.23). After normalization of thyroid function, the weight of hypothyroid patients decreased from 70.93+/-10.06 kg to 68.68+/-10.14 (p=0.000), while the weight of hyperthyroid patients increased from 65.45+/-11.64 kg to 68.37+/-12.80 (p=0.000). Their mean BMI was 26.22+/-3.36 and 27.57+/-4.98 (p=0.361) for hypo- and hyperthyroid patients, respectively. 58.8% and 64.7% patients remained in the overweight/obesity range in each group (p=0.72). Conclusion: Untreated thyroid dysfunction is not associated with BMI. Normalization of thyroid levels significantly changed the weight of patients, but remaining most patients within overweight ranges

Identification of candidate host serum and saliva biomarkers for a better diagnosis of active and latent tuberculosis infection

In our work, we aim to identify new candidate host biomarkers to discriminate between active TB patients (n = 28), latent infection (LTBI; n = 27) and uninfected (NoTBI; n = 42) individuals. For that, active TB patients and their contacts were recruited that donated serum and saliva samples. A multiplex assay was performed to study the concentration of different cytokines, chemokines and growth factors. Proteins with significant differences between groups were selected and logistic regression and the area under the ROC curve (AUC) was used to assess the diagnostic accuracy. The best marker combinations that discriminate active TB from NoTBI contacts were [IP-10 + IL-7] in serum and [Fractalkine + IP-10 + IL-1α + VEGF] in saliva. Best discrimination between active TB and LTBI was achieved using [IP-10 + BCA-1] in serum (AUC = 0.83) and IP-10 in saliva (p = 0.0007; AUC = 0.78). The levels of TNFα (p = 0.003; AUC = 0.73) in serum and the combination of [Fractalkine+IL-12p40] (AUC = 0.83) in saliva, were able to differentiate between NoTBI and LTBI contacts. In conclusion, different individual and combined protein markers could help to discriminate between active TB and both uninfected and latently-infected contacts. The most promising ones include [IP-10 + IL-7], [IP-10 + BCA-1] and TNFα in serum and [Fractalkine + IP-10 + IL-1α + VEGF], IP-10 and [Fractalkine+IL-12p40] in saliva.Xunta de Galicia | Ref. ED431C 2016/041Ministerio de Ecucación, Cultura y Deporte | Ref. FPU 13/0302

Decline of tuberculosis rates and Covid-19 pandemic. Fact or fiction?

Las medidas de distanciamiento social y aislamiento respiratorio, incluyendo el uso generalizado de mascarillas, contribuyen de manera positiva al descenso de la incidiencia de TB en nuestro medio