Current Trends and Future Directions In The Practice Of High-Level Data Modeling: An Empirical Study

Large-scale organizations are increasingly promoting more collaborative and collective work practices across organizational boarders. A predominant way to achieve better collaboration in largescale heterogeneous contexts is to establish an integrated and standardized technological infrastructure. Ethnographically inspired studies, on the other hand, have challenged such perspective and illustrated that generic technology does not fit in local contexts and needs to be worked-around. Similarly, this paper empirically exemplifies local workarounds and illustrates ongoing and persistently imperfect integration of a collaborative infrastructure in a global oil and gas company. More importantly, however, our analysis focuses on how integrated technology is used across contexts. We illustrate how local workarounds, as a result of tight technological integration, shape use patterns across contexts. Integrated systems establish interdependencies across contexts, thus, the use implies cross-contextual rather than local enactment. Since the trajectory of enactment is influenced by cross-contextual constrains, our study is addressing the existing overemphasis on studying/analysing the use of technology in isolated local contexts. Practically, our study suggests considering workarounds as an intrinsic part of every day work, which should be calculated as additional costs of making the generic technology to work in practice

Cancer Genomics Identifies Regulatory Gene Networks Associated with the Transition from Dysplasia to Advanced Lung Adenocarcinomas Induced by c-Raf-1

Background: Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecular causes of disease a transgenic mouse model was investigated where targeted expression of the serine threonine kinase c-Raf to respiratory epithelium induced initialy dysplasia and subsequently adenocarcinomas. This enables dissection of genetic events associated with precancerous and cancerous lesions. Methodology/Principal Findings: By laser microdissection cancer cell populations were harvested and subjected to whole genome expression analyses. Overall 473 and 541 genes were significantly regulated, when cancer versus transgenic and non-transgenic cells were compared, giving rise to three distinct and one common regulatory gene network. At advanced stages of tumor growth predominately repression of gene expression was observed, but genes previously shown to be upregulated in dysplasia were also up-regulated in solid tumors. Regulation of developmental programs as well as epithelial mesenchymal and mesenchymal endothelial transition was a hall mark of adenocarcinomas. Additionaly, genes coding for cell adhesion, i.e. the integrins and the tight and gap junction proteins were repressed, whereas ligands for receptor tyrosine kinase such as epi- and amphiregulin were up-regulated. Notably, Vegfr- 2 and its ligand Vegfd, as well as Notch and Wnt signalling cascades were regulated as were glycosylases that influence cellular recognition. Other regulated signalling molecules included guanine exchange factors that play a role in an activation of the MAP kinases while several tumor suppressors i.e. Mcc, Hey1, Fat3, Armcx1 and Reck were significantly repressed. Finally, probable molecular switches forcing dysplastic cells into malignantly transformed cells could be identified. Conclusions/Significance: This study provides insight into molecular pertubations allowing dysplasia to progress further to adenocarcinoma induced by exaggerted c-Raf kinase activity

ARB Linderman, Rediscovering Irregular Warfare: Colin Gubbins and the Origins of Britain’s Special Operations Executive

Much has been written recently on something called ‘hybrid warfare’. While there isno one agreed definition, the current storm of books, articles and blog piecesclaiming authority on the subject concur broadly that it is a novel, 21st-centuryconcept centring on using local malcontents, organised covertly by secret servicesinto plausibly deniable paramilitary formations supported by agents and special forces,propaganda and diplomatic pressure to achieve strategic aims in lieu of overt militaryforce

Orde Wingate and the British Army, 1922-1944

Major General Orde Wingate (1903–44) was the most controversial British military commander of the Second World War, due to his idiosynchratic leadership style, which led some to question his sanity, and his fiercely pro-Zionist stance. More than sixty years after his death he still splits opinion amongst soldiers, academics and writers

Orde Wingate in the Sudan, 1928-1933: Formative Experiences of the Chindit Commander

This short paper looks at Orde Wingate's role in armed policing and counter-bandit operations in Sudan during his time with the Sudan Defence Force

The Royal Army Education Corps in the Gulf Conflict of 1990-91

The official history of the Royal Army Education Corps' involvement in Operation 'Desert Storm', the liberation of Kuwait from Iraqi occupation in 1991, their roles including prisoner of war interrogation, psychological operations, IT services and acting as interpreters for senior officers