Serum antibodies and shedding of infectious porcine circovirus 2 into colostrum and milk of vaccinated and unvaccinated naturally infected sows

Serum antibodies and shedding of porcine circovirus type 2 (PCV2) into lacteal secretions were examined in naturally infected sows. Total (TA) and neutralising (NA) antibodies against PCV2 were evaluated in serum and colostrum from 20 vaccinated (Vac) and 21 unvaccinated (N-vac) sows. Anti-PCV2 IgA titres and PCV2 infectious titres were determined in colostrum and milk. All sows had high TA and NA levels in serum and colostrum. Infectious PCV2 was detected in 22/41 colostrum samples (7/20 Vac and 15/21 NVac sows) and 5/20 milk samples (1/5 Vac and 4/15 N-Vac sows). Anti-PCV2 IgA was found in high levels in colostrum and varying levels in milk. Infectious PCV2 may be present in milk and colostrum of naturally infected sows, even in the presence of NA

Fetal infections and antibody profiles in pigs naturally infected with porcine circovirus type 2 (PCV2)

The aim of this study was to describe early infections with porcine circovirus type 2 (PCV2) in naturally infected piglets and the piglets' serologic profiles. A total of 20 sows (15 PCV2-vaccinated and 5 unvaccinated) and 100 newborn piglets were studied. Colostrum and serum of the sows and serum of the presuckling piglets were obtained on the day of parturition. Milk samples were collected on day 20 postpartum. Blood samples were taken and the piglets weighed on days 1, 20, 42, 63, and 84 postpartum. Colostrum and milk were evaluated for infectious PCV2 and for PCV2 total antibody (TA), neutralizing antibody (NA), and IgA. Serum samples were evaluated for PCV2 TA, NA, IgA, IgM, and DNA. The sows had high levels of TA and NA in serum and colostrum; however, 11 and 5, respectively, of the 20 colostrum and milk samples contained infectious PCV2. In the serum, PCV2 DNA and IgM were detected in 17 and 5, respectively, of the 20 sows. Nine piglets were born with PCV2 antibodies, which indicates in utero transmission of PCV2 after the period of immunocompetence (. 70 d of gestation). On day 1 postpartum, PCV2 DNA was detected in 29 of the 100 serum samples from the piglets. There was no difference between the weights of viremic and nonviremic piglets throughout the study. In conclusion, even on farms with sows that have high PCV2 antibody titers, vertical transmission of PCV2 may occur, resulting in piglet infection

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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