Carriebowlinol, an Antimicrobial Tetrahydroquinolinol from an Assemblage of Marine Cyanobacteria Containing a Novel Taxon

A combined biodiversity- and bioassay-guided natural products discovery approach was used to explore new groups of marine cyanobacteria for novel secondary metabolites with ecologically relevant bioactivities. Phylogenetic analysis of cyanobacterial collections from Belize revealed a new taxon not previously well explored for natural products. The new alkaloid 5-hydroxy-4-(chloromethyl)-5,6,7,8-tetrahydroquinoline (<b>1</b>), named carriebowlinol, and the known compound lyngbic acid (<b>2</b>) were isolated from a nonpolar extract and identified by NMR and MS techniques. Compounds <b>1</b> and <b>2</b> inhibited the growth of pathogenic and saprophytic marine fungi, and <b>1</b> inhibited the growth of marine bacteria, suggesting an antimicrobial ecological function