Representative SEM images of plasma fibrin clots.

<p>(A) a patient with heavy menstrual bleeding (HMB). (B) a healthy control subject. Magnification 5000x. Scale bar 5 μm.</p

ROC curve for tissue plasminogen activator antigen (tPA:Ag).

<p>AUC denotes area under curve; SE, standard error; CI, confidence intervals.</p

Risk of heavy menstrual bleeding according to permeability coefficient (K_s).

<p>^a Odds ratios (ORs) adjusted for age, BMI, glucose and fibrinogen; CI, confidence interval.</p><p>Risk of heavy menstrual bleeding according to permeability coefficient (K_s).</p

Comparisons of fibrin clot variables and thrombin generation parameters in patients with heavy menstrual bleeding and controls.

<p>K_s, permeability coefficient; ΔAbs_max (405 nm), maximum absorbancy of a fibrin gel at 405 nm; CLT, clot lysis time; D-D_rate, maximum rate of increase in D-dimer levels; ETP, endogenous thrombin potential; Peak thrombin generation, maximum concentration of thrombin generated.</p><p>^aData are shown as median (interquartile range); Comparison of subjects between 2 groups with analysis of Mann Whitney U test;</p><p>^bData are shown as mean ± standard deviation; Comparison of subjects between 2 groups with analysis of Student test.</p><p>Comparisons of fibrin clot variables and thrombin generation parameters in patients with heavy menstrual bleeding and controls.</p

Risk of heavy menstrual bleeding according to clot lysis time (CLT).

<p>^a ORs adjusted for age, BMI, glucose and fibrinogen. Abbreviations: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125069#pone.0125069.t004" target="_blank">Table 4</a>.</p><p>Risk of heavy menstrual bleeding according to clot lysis time (CLT).</p

Coagulation factors in patients with heavy menstrual bleeding and controls.

<p>F, factor.</p><p>Data are shown as median (interquartile range) or mean ± standard deviation (for FXIII); Comparison between 2 groups using Mann Whitney U test or Student t-test.</p><p>Coagulation factors in patients with heavy menstrual bleeding and controls.</p

Characteristics of patients with heavy menstrual bleeding and controls.

<p>BMI, body mass index; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein; INR, international normalized ratio; APTT, activated partial thromboplastin time; tPA:Ag, tissue plasminogen activator antigen; PAI- 1:Ag, plasminogen activator inhibitor-1 antigen; PAP, plasmin-alpha 2-antiplasmin complexes; vWF:Ag, von Willebrand factor antigen.</p><p>^aData are shown as median (interquartile range); Comparison between 2 groups using the Mann Whitney U test;</p><p>^bData are shown as mean ± standard deviation; Comparison between 2 groups using the Student t-test;</p><p>^cComparison between 2 groups using χ² test.</p><p>Characteristics of patients with heavy menstrual bleeding and controls.</p

ROC curve for clot lysis time (CLT).

<p>AUC denotes area under curve; SE, standard error; CI, confidence intervals.</p

Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in VEGF (vascular endothelial growth factor).

<p>Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in VEGF (vascular endothelial growth factor).</p

Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in Interleukin- 10 (IL-10).

<p>Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in Interleukin- 10 (IL-10).</p