5 research outputs found
A Novel Approach to the Design of Phosphonate Inhibitors of Protein Tyrosine Phosphatase
Unusually High Selectivity of Guest Exchange in <i>tert</i>-Butylthiacalix[4]arene Clathrate Producing More Thermostable Inclusion and Memory of Guest
New properties, earlier unknown for calixarenes, were
found for <i>tert</i>-butylthiacalix[4]arene (<b>1</b>) clathrate with
1,2-dichloroethane (DCE). Guest exchange in <b>1</b>·1.90DCE
for vapors of some organic compounds gives clathrates, which are more
thermostable at 34–59 °C than those prepared by direct
saturation of guest-free <b>1</b> with pure guests. Besides,
guest exchange may produce clathrates that cannot be formed by direct
saturation in binary host–guest systems. Some compounds, like
water, toluene, and trichloroethylene, expel DCE from its clathrate
with <b>1</b> but are not included above the trace level. Residual
contents of DCE in clathrate may be controlled by variation of water
and <b>1</b>·1.90DCE ratio in the studied system. Host <b>1</b> can remember methanol after its elimination from the guest
exchange product. This memory can be read as an exoeffect by differential
scanning calorimetry. Only methanol and only after guest exchange
is remembered giving an example of a genuine molecular recognition