9 research outputs found
Intravitrealna primjena bevacizumaba u lijeÄenju neovaskularnog glaukoma
The aim of the study was to assess short-term efficacy of intravitreal bevacizumab in a series of patients with neovascular glaucoma. Eleven patients with neovascular glaucoma and symptomatic elevation of intraocular pressure were treated with 1.25 mg/0.1 mL of bevacizumab. In three patients, intravitreal bevacizumab was administered preoperatively, one day before pars plana vitrectomy. Additional therapy was only performed if topical medication failed to result in satisfactory control of intraocular pressure. Patients were followed-up for a minimum of 8 weeks. In all study patients, intravitreal application of bevacizumab resulted in marked regression of iris neovascularization within the first three postoperative days. Appropriate control of intraocular pressure was achieved in seven patients, whereas four patients required additional therapy for intraocular pressure regulation. No side effects of intravitreal bevacizumab were recorded. Thus, intravitreal bevacizumab seems to be a potent adjunct in the management of neovascular glaucoma. Additional studies of bevacizumab long-term safety and efficacy are warranted.Cilj ove studije bio je procijeniti kratkotrajni uÄinak intravitrealne primjene bevacizumaba u skupini bolesnika s neovaskularnim glaukomom. U studiju je bilo ukljuÄeno jedanaestoro bolesnika s neovaskularnim glaukomom i simptomatskim poviÅ”enjem oÄnog tlaka. Kod svih bolesnika primijenjen je bevacizumab u dozi od 1,25/0,1 mL intravitrealno. Kod troje bolesnika je bevacizumab primijenjen jedan dan prije pars plana vitrektomije. Dodatna antiglaukomska terapija primijenjena je samo kod onih bolesnika u kojih oÄni tlak nije bio dobro kontroliran lokalnom antiglaukomskom terapijom. NajkraÄe razdoblje praÄenja bolesnika bilo je 8 tjedana. Intravitrealna primjena bevacizumaba dovela je kod svih bolesnika do znaÄajne regresije neovaskularizacije Å”arenice, Å”to je treÄega dana od primjene bevacizumaba potvrÄeno biomikroskopski te fluoresceinskom angiografijom. U sedmoro bolesnika je oÄni tlak bio dobro kontroliran samo lokalnom antiglaukomskom terapijom. Kod Äetvoro bolesnika bilo je potrebno daljnje kirurÅ”ko antiglaukomsko lijeÄenje. Nisu zabilježene nuspojave kao niti komplikacije za vrijeme ili poslije intravitrealne injekcije bevacizumaba. ZakljuÄuje se kako se intravitrealna primjena bevacizumaba Äini dobrom dodatnom metodom u kombinaciji s ostalim terapijskim modalitetima lijeÄenja neovaskularnog glaukoma. Dodatne studije kojima se ispituje dugotrajniji uÄinak i sigurnost intravitrealne primjene bevacizumaba su u tijeku i one Äe doprinijeti boljem razumijevanju farmakokinetike, toksiÄnosti i putova primjene bevacizumaba u lijeÄenju neovaskularnog glaukoma
MorfoloŔke i angiografske promjene periferne mrežnice u bolesnika sa senilnom makularnom degeneracijom [Morphologic and angiographic peripheral retinal changes in patients with age related macular degeneration]
Age related macular disease (AMD), are the most prominent cause of central visual acuity
loss in population older than 55 y.
Wet form is more serious condition, because in short time, if not treated, central visual acuity
can be permanently lost, so the estimation of the progression risk from dry to wet type,
becomes important. Recent data suggest, that at retinal periphery, can exists some important
morphologic changes like peripheral drusen and reticular pigmentary changes, that usually
are connected more frequently with wet AMD form .
Estimation of disease progression has been usually done with standard fundus cameras that
can scan only the posterior pole and medial part of the retina which is approximately 45-50
degree of all retina.
The wide field camera which is used in this study, was able to scan almost 200 degree of
retina, documented peripheral retinal changes and their angiographic characteristics.
The aim of the study was to compare morphologic characteristics of peripheral retinal changes
in patients with AMD with healthy control group, and to compare morphologic and
angiographic characteristics of peripheral retinal changes between two types of AMD.
In study was included 152 patients with signs of AMD and 150 healthy controls . Statistically
significant difference were observed in frequency of drusen, reticular pigmented
degenerations and āpaving stoneā degenerations, which are more frequently observed in
AMD group.
āWhite without pressureā degeneration were more frequently observed in control healthy
group. Drusen are statistically significantly occurred and more widely spreaded in dry type of
AMD .
There were no statistically significant difference between wet and dry type of AMD, nor in
type , frequency or localization of morphologic and angiographic characteristics of peripheral
retinal changes
Morphologic and angiographic peripheral retinal changes in patients with age related macular degeneration
Senilna makularna degeneracija (SMD), jedna je od vodeÄih bolesti oka s gubitkom vidne
oŔtrine populacije starije od 55 g. Vlažni oblik senilne makularne degeneracije je mnogo
ozbiljnije stanje jer, ukoliko se ne lijeÄi, u kratkom vremenskom roku dovodi do gubitka
centralne vidne oŔtrine.
Novije spoznaje sugeriraju da se kljuÄne morfoloÅ”ke znaÄajke nalaze i na periferiji mrežnice,
a njihovo prisustvo povezano je sa težim oblicima senilne makularne degeneracije ili može
imati važne implikacije za rizik napredovanja bolesti.
Dostupnost perifernih promjena vizualizaciji i dokumentaciji do sada bila je ograniÄena na
radove koji su koristili sistem standardnih fundus kamera sa Ŕirinom kuta od maksimalno 45-
50 stupnjeva.
Sistem Å”irokokutne fundus kamere,koji je koriÅ”ten u ovom istraživanju, omoguÄava
vizualizaciju i dokumentaciju periferije do 200 stupnjeva.
Cilj ovog rada bio je usporediti pojavnost, proŔirenost i lokalizaciju morfoloŔkih promjena
periferne mrežnice u skupini bolesnika sa senilnom makularnom degeneracijom s
morfoloŔkim karakteristikama zdrave kontrolne skupine ispitanika, te ispitati angiografske
karakteristike perifernih promjena mrežnice unutar skupine bolesnika sa SMD-om.
U studiju je ukljuÄeno 152 ispitanika s kliniÄkom slikom senilne makularne degeneracije i
150 kontrolnih zdravih ispitanika starijih od 50 godina.
MorfoloÅ”kom analizom svih oÄiju sa SMD-om, ustanovljena je statistiÄki znaÄajna razlika u
pojavnosti druza, retikularnih pigmentnih promjena i āpaving stoneā promjena koje se ÄeÅ”Äe
javljaju u skupini bolesnika sa SMD-om u odnosu na kontrolnu skupinu. āWhite without
pressureā ili blijedilo bez pritiska - degenerativna je promjena koja se statistiÄki znaÄajno
ÄeÅ”Äe javlja u kontrolnoj skupini.
Usporednom analizom morfoloÅ”kih i angiografskih perifernih promjena uoÄava se statistiÄki
znaÄajna razlika samo u pojavnosti druza koje su ÄeÅ”Äe vizualizirane u suhom tipu SMD-a.
Nije uoÄena statistiÄki znaÄajna razlika za sve ostale ispitivane morfoloÅ”ke i angiografske
promjene izmeÄu suhog i vlažnog tipa SMD-a, s obzirom na proÅ”irenost ili lokalizaciju
prema ekvatoru oka.Age related macular disease (AMD), are the most prominent cause of central visual acuity
loss in population older than 55 y.
Wet form is more serious condition, because in short time, if not treated, central visual acuity
can be permanently lost, so the estimation of the progression risk from dry to wet type,
becomes important. Recent data suggest, that at retinal periphery, can exists some important
morphologic changes like peripheral drusen and reticular pigmentary changes, that usually
are connected more frequently with wet AMD form .
Estimation of disease progression has been usually done with standard fundus cameras that
can scan only the posterior pole and medial part of the retina which is approximately 45-50
degree of all retina.
The wide field camera which is used in this study, was able to scan almost 200 degree of
retina, documented peripheral retinal changes and their angiographic characteristics.
The aim of the study was to compare morphologic characteristics of peripheral retinal changes
in patients with AMD with healthy control group, and to compare morphologic and
angiographic characteristics of peripheral retinal changes between two types of AMD.
In study was included 152 patients with signs of AMD and 150 healthy controls . Statistically
significant difference were observed in frequency of drusen, reticular pigmented
degenerations and āpaving stoneā degenerations, which are more frequently observed in
AMD group.
āWhite without pressureā degeneration were more frequently observed in control healthy
group. Drusen are statistically significantly occurred and more widely spreaded in dry type of
AMD .
There were no statistically significant difference between wet and dry type of AMD, nor in
type , frequency or localization of morphologic and angiographic characteristics of peripheral
retinal changes
Morphologic and angiographic peripheral retinal changes in patients with age related macular degeneration
Senilna makularna degeneracija (SMD), jedna je od vodeÄih bolesti oka s gubitkom vidne
oŔtrine populacije starije od 55 g. Vlažni oblik senilne makularne degeneracije je mnogo
ozbiljnije stanje jer, ukoliko se ne lijeÄi, u kratkom vremenskom roku dovodi do gubitka
centralne vidne oŔtrine.
Novije spoznaje sugeriraju da se kljuÄne morfoloÅ”ke znaÄajke nalaze i na periferiji mrežnice,
a njihovo prisustvo povezano je sa težim oblicima senilne makularne degeneracije ili može
imati važne implikacije za rizik napredovanja bolesti.
Dostupnost perifernih promjena vizualizaciji i dokumentaciji do sada bila je ograniÄena na
radove koji su koristili sistem standardnih fundus kamera sa Ŕirinom kuta od maksimalno 45-
50 stupnjeva.
Sistem Å”irokokutne fundus kamere,koji je koriÅ”ten u ovom istraživanju, omoguÄava
vizualizaciju i dokumentaciju periferije do 200 stupnjeva.
Cilj ovog rada bio je usporediti pojavnost, proŔirenost i lokalizaciju morfoloŔkih promjena
periferne mrežnice u skupini bolesnika sa senilnom makularnom degeneracijom s
morfoloŔkim karakteristikama zdrave kontrolne skupine ispitanika, te ispitati angiografske
karakteristike perifernih promjena mrežnice unutar skupine bolesnika sa SMD-om.
U studiju je ukljuÄeno 152 ispitanika s kliniÄkom slikom senilne makularne degeneracije i
150 kontrolnih zdravih ispitanika starijih od 50 godina.
MorfoloÅ”kom analizom svih oÄiju sa SMD-om, ustanovljena je statistiÄki znaÄajna razlika u
pojavnosti druza, retikularnih pigmentnih promjena i āpaving stoneā promjena koje se ÄeÅ”Äe
javljaju u skupini bolesnika sa SMD-om u odnosu na kontrolnu skupinu. āWhite without
pressureā ili blijedilo bez pritiska - degenerativna je promjena koja se statistiÄki znaÄajno
ÄeÅ”Äe javlja u kontrolnoj skupini.
Usporednom analizom morfoloÅ”kih i angiografskih perifernih promjena uoÄava se statistiÄki
znaÄajna razlika samo u pojavnosti druza koje su ÄeÅ”Äe vizualizirane u suhom tipu SMD-a.
Nije uoÄena statistiÄki znaÄajna razlika za sve ostale ispitivane morfoloÅ”ke i angiografske
promjene izmeÄu suhog i vlažnog tipa SMD-a, s obzirom na proÅ”irenost ili lokalizaciju
prema ekvatoru oka.Age related macular disease (AMD), are the most prominent cause of central visual acuity
loss in population older than 55 y.
Wet form is more serious condition, because in short time, if not treated, central visual acuity
can be permanently lost, so the estimation of the progression risk from dry to wet type,
becomes important. Recent data suggest, that at retinal periphery, can exists some important
morphologic changes like peripheral drusen and reticular pigmentary changes, that usually
are connected more frequently with wet AMD form .
Estimation of disease progression has been usually done with standard fundus cameras that
can scan only the posterior pole and medial part of the retina which is approximately 45-50
degree of all retina.
The wide field camera which is used in this study, was able to scan almost 200 degree of
retina, documented peripheral retinal changes and their angiographic characteristics.
The aim of the study was to compare morphologic characteristics of peripheral retinal changes
in patients with AMD with healthy control group, and to compare morphologic and
angiographic characteristics of peripheral retinal changes between two types of AMD.
In study was included 152 patients with signs of AMD and 150 healthy controls . Statistically
significant difference were observed in frequency of drusen, reticular pigmented
degenerations and āpaving stoneā degenerations, which are more frequently observed in
AMD group.
āWhite without pressureā degeneration were more frequently observed in control healthy
group. Drusen are statistically significantly occurred and more widely spreaded in dry type of
AMD .
There were no statistically significant difference between wet and dry type of AMD, nor in
type , frequency or localization of morphologic and angiographic characteristics of peripheral
retinal changes
Morphologic and angiographic peripheral retinal changes in patients with age related macular degeneration
Senilna makularna degeneracija (SMD), jedna je od vodeÄih bolesti oka s gubitkom vidne
oŔtrine populacije starije od 55 g. Vlažni oblik senilne makularne degeneracije je mnogo
ozbiljnije stanje jer, ukoliko se ne lijeÄi, u kratkom vremenskom roku dovodi do gubitka
centralne vidne oŔtrine.
Novije spoznaje sugeriraju da se kljuÄne morfoloÅ”ke znaÄajke nalaze i na periferiji mrežnice,
a njihovo prisustvo povezano je sa težim oblicima senilne makularne degeneracije ili može
imati važne implikacije za rizik napredovanja bolesti.
Dostupnost perifernih promjena vizualizaciji i dokumentaciji do sada bila je ograniÄena na
radove koji su koristili sistem standardnih fundus kamera sa Ŕirinom kuta od maksimalno 45-
50 stupnjeva.
Sistem Å”irokokutne fundus kamere,koji je koriÅ”ten u ovom istraživanju, omoguÄava
vizualizaciju i dokumentaciju periferije do 200 stupnjeva.
Cilj ovog rada bio je usporediti pojavnost, proŔirenost i lokalizaciju morfoloŔkih promjena
periferne mrežnice u skupini bolesnika sa senilnom makularnom degeneracijom s
morfoloŔkim karakteristikama zdrave kontrolne skupine ispitanika, te ispitati angiografske
karakteristike perifernih promjena mrežnice unutar skupine bolesnika sa SMD-om.
U studiju je ukljuÄeno 152 ispitanika s kliniÄkom slikom senilne makularne degeneracije i
150 kontrolnih zdravih ispitanika starijih od 50 godina.
MorfoloÅ”kom analizom svih oÄiju sa SMD-om, ustanovljena je statistiÄki znaÄajna razlika u
pojavnosti druza, retikularnih pigmentnih promjena i āpaving stoneā promjena koje se ÄeÅ”Äe
javljaju u skupini bolesnika sa SMD-om u odnosu na kontrolnu skupinu. āWhite without
pressureā ili blijedilo bez pritiska - degenerativna je promjena koja se statistiÄki znaÄajno
ÄeÅ”Äe javlja u kontrolnoj skupini.
Usporednom analizom morfoloÅ”kih i angiografskih perifernih promjena uoÄava se statistiÄki
znaÄajna razlika samo u pojavnosti druza koje su ÄeÅ”Äe vizualizirane u suhom tipu SMD-a.
Nije uoÄena statistiÄki znaÄajna razlika za sve ostale ispitivane morfoloÅ”ke i angiografske
promjene izmeÄu suhog i vlažnog tipa SMD-a, s obzirom na proÅ”irenost ili lokalizaciju
prema ekvatoru oka.Age related macular disease (AMD), are the most prominent cause of central visual acuity
loss in population older than 55 y.
Wet form is more serious condition, because in short time, if not treated, central visual acuity
can be permanently lost, so the estimation of the progression risk from dry to wet type,
becomes important. Recent data suggest, that at retinal periphery, can exists some important
morphologic changes like peripheral drusen and reticular pigmentary changes, that usually
are connected more frequently with wet AMD form .
Estimation of disease progression has been usually done with standard fundus cameras that
can scan only the posterior pole and medial part of the retina which is approximately 45-50
degree of all retina.
The wide field camera which is used in this study, was able to scan almost 200 degree of
retina, documented peripheral retinal changes and their angiographic characteristics.
The aim of the study was to compare morphologic characteristics of peripheral retinal changes
in patients with AMD with healthy control group, and to compare morphologic and
angiographic characteristics of peripheral retinal changes between two types of AMD.
In study was included 152 patients with signs of AMD and 150 healthy controls . Statistically
significant difference were observed in frequency of drusen, reticular pigmented
degenerations and āpaving stoneā degenerations, which are more frequently observed in
AMD group.
āWhite without pressureā degeneration were more frequently observed in control healthy
group. Drusen are statistically significantly occurred and more widely spreaded in dry type of
AMD .
There were no statistically significant difference between wet and dry type of AMD, nor in
type , frequency or localization of morphologic and angiographic characteristics of peripheral
retinal changes
Ophthalmologist in Patientsā Eyes
It seems that patient\u27s knowledge about ophthalmologist\u27s work is very insufficient, especially about what type of
examination should be undertaken for refraction condition during the Ā»simpleĀ« eye check-up and which serious systemic
diseases could be discovered thorough eye examinations. The aim of the study was to determine patients\u27 knowledge
about ophthalmologist examinations during the check-up for refraction condition, knowledge about differences
between ophthalmologists and opticians, main sources of patients\u27 ophthalmologic cognition and the main reasons for
coming to special locations. Patients (311) were examined by applying the questionnaire, immediately before the eye
check-up at three various refraction units. Statistical analysis used Chi-square test and test of significance between
proportions, except for patientsā age where Student t-test was used. Differences were statistically significant at p=0.05.
The findings show that the patientsā knowledge about eye examination during the check-ups for refraction abnormalities
was not satisfactory. Twenty-two percent (22%) of examined patients did not know the differences between ophthalmologists
and opticians and 16 % believed that after computer testing of refraction further ophthalmologic examinations
were not necessary. The main sources of medical cognition were the mass media while twenty percent (20%) of the
participating patients named doctorās lectures as the source of their cognition. This study revealed that a lot of work
needs to be done to improve patients\u27 education and indirectly for better screening of very serious systemic diseases and
blind threatening diseases which could be discovered during the first visit for spectacle prescription
Phacoemulsification and Silicone Oil Removal Through The Planned Posterior Capsulorhexis
The purpose of the study was to present operative technique and results of a passive hydrodynamic expression of silicone
oil through planned posterior capsulorhexis during cataract surgery in patients after pars plana vitrectomy. The
retrospective analysis was done on 57 eyes with cataract after a previous pars plana vitrectomy, operated on between
2001 and 2004 at the Clinical hospital Ā»Sestre milosrdniceĀ« Zagreb. Preoperative and postoperative best corrected visual
acuity (BCVA), preoperative and postoperative intraocular pressure (IOP), and postoperative complications were
reviewed. Visual acuity improved or stabilized in all patients with an attached retina. Retinal detachment occurred in
11 eyes. Transient vitreous hemorrhage, that resolved within 1 week of surgery without treatment, was observed in 4
eyes. Asymptomatic intraocular lens (IOL) decentration occurred in 2 eyes. Our findings suggest that silicone oil removal
and cataract surgery can be performed as a single procedure in selected patients in the absence of macular
pucker and retinal reproliferation, and in a presence of a stable retina
Common Variant in Myocilin Gene Is Associated with High Myopia in Isolated Population of KorÄula Island, Croatia
Aim To study the association between genetic variants in
myocilin and collagen type I alpha 1 genes and high myopia
in an isolated island population.
Methods A total of 944 examinees from the genetic epidemiology
study conducted on the island of KorÄula, Croatia,
were included in the study. We selected 2 short nucleotide
polymorphisms (SNP) available in our genome-wide
scan set of SNPs that were previously associated with high
myopia and used them to replicate previous claims of possible
association.
Results Nineteen cases of high myopia, defined as the refraction
of ā¤-6.00 diopters, were identified and included
in the analysis. We showed that rs2075555 in the COL1A1
gene was not associated with high myopia. In contrast,
rs2421853 in the myocilin gene was significantly associated
in both bivariate (P = 0.006) and age- and sex-adjusted
analysis (P = 0.049).
Conclusion Myocilin seems to be a very strong candidate
for explaining some of the pathophysiological pathways
leading to the development of both glaucoma and high
myopia. As our finding was obtained in a relatively underpowered
sample, further research and replication of these
results is needed