Visible relations in online communities : modeling and using social networks

The Internet represents a unique opportunity for people to interact with each other across time and space, and online communities have existed long before the Internet's solidification in everyday living. There are two inherent challenges that online communities continue to contend with: motivating participation and organizing information. An online community's success or failure rests on the content generated by its users. Specifically, users need to continually participate by contributing new content and organizing existing content for others to be attracted and retained. I propose both participation and organization can be enhanced if users have an explicit awareness of the implicit social network which results from their online interactions. My approach makes this normally ``hidden" social network visible and shows users that these intangible relations have an impact on satisfying their information needs and vice versa. That is, users can more readily situate their information needs within social processes, understanding that the value of information they receive and give is influenced and has influence on the mostly incidental relations they have formed with others. First, I describe how to model a social network within an online discussion forum and visualize the subsequent relationships in a way that motivates participation. Second, I show that social networks can also be modeled to generate recommendations of information items and that, through an interactive visualization, users can make direct adjustments to the model in order to improve their personal recommendations. I conclude that these modeling and visualization techniques are beneficial to online communities as their social capital is enhanced by "weaving" users more tightly together

Ceramic Consumption in a Boston Immigrant Tenement

In the late nineteenth and early twentieth centuries, Boston’s North End became home to thousands of European immigrants, mostly from Ireland and Italy. The majority of these immigrant families lived in crowded tenement apartments and earned their wages from low-paying jobs such as manual laborers or store clerks. The Ebenezer Clough House at 21 Unity Street was originally built as a single-family colonial home in the early eighteenth century but was later repurposed as a tenement in the nineteenth century. In 2013, the City of Boston Archaeology Program excavated the rear lot of the Clough House, recovering 36,465 artifacts, including 4,298 ceramic sherds, across 14 site-wide contexts. One context, the main midden, has been interpreted as a multi-use household trash deposit dating from the 1870s to the 1910s, during which the tenement was home to a rotation of over 100 working-class families, most of them immigrants. This project couples ceramic analysis with in-depth archival research to illuminate the consumption strategies of Boston’s immigrant working class. I conclude that tenants primarily used decorated but mismatched and older ceramic ware types, valuing thrift and prioritizing family needs while consuming differently than their middle-class counterparts

Estimating Oral Anticoagulant Comparative Effectiveness in the Setting of Effect Heterogeneity: Comparing Clinical Trial Transport and Non-experimental Epidemiologic Methods

Oral anticoagulation is vital to the health of patients with atrial fibrillation at elevated risk of stroke. The first treatment for these patients, warfarin, was approved in the 1990s. Since 2010, dabigatran has been available for use after demonstrating non-inferiority to warfarin in a randomized controlled trial. Non-experimental studies comparing dabigatran to warfarin and censoring at treatment discontinuation have shown greater benefits than the original trial for all-cause mortality and attenuated harms for gastrointestinal bleeding. The goals of this dissertation, then, were to compute and compare 1) estimates of the absolute-scale effects of dabigatran vs warfarin initiation on ischemic stroke (IS), death, and gastrointestinal bleeding (GIB) in trial-eligible older adults using non-experimental Medicare data and 2) estimates of those effects in the same populations using inverse odds of sampling weights to transport results from the Randomized Evaluation of Long-Term Anticoagulation (RE-LY) trial. First, we conducted a propensity score weighted non-experimental study with the new user active comparator design in a 20% random sample of Medicare beneficiares. We estimated on-treatment two-year risk differences for IS (RD for dabigatran users, RDdabi: -0.67%, 95% CI -1.10%, -0.24%), mortality (RDdabi: -2.98%, 95% CI -3.97%, -1.95%) and GIB (RDdabi: 0.51%, 95% CI -0.30%, 1.31%). Intention-to-treat estimates showed attenuation for mortality (RDdabi: -1.65%, 95% CI -2.32%, -0.98%) and reversal for IS (RDdabi: 0.16%, 95% CI -0.20%, 0.52%). Next, we reweighted RE-LY to resemble the Medicare new users of warfarin or dabigatran (restricted to those with less than 15% predicted probability of frailty). After weighting, we estimated on-treatment two-year risk differences for IS (RDdabi: -0.77%, 95% CI -1.69%, 0.14%), death (RDdabi: -0.57%, 95% CI -1.83%, 0.68%) and GIB (RDdabi: 1.75%, 95% CI 0.76%, 2.74%). These twin studies show non-experimental and weighted trial analyses comparing dabigatran to warfarin agree much better for IS than they do for mortality or GIB. This could be due to confounding in the non-experimental estimates, missing treatment effect modifiers, or outcome misclassification. Researchers should be cautious about comparing studies without considering treatment effect heterogeneity and differences in adherence across study populations.Doctor of Philosoph

Psychophysical measures of visual function and everyday perceptual experience in a case of congenital stationary night blindness

An appreciation of the relation between laboratory measures of visual deficit and everyday perceptual experience is fundamental to understanding the impact of a visual condition on patients and so to a fuller characterization of the disorder. This study aims to understand better the interpretative processes by which modified sensory information is perceived by a patient with congenital stationary night blindness and the adaptive strategies that are devised to deal with their measurable visual loss. Psychophysical measurements of temporal resolution, spectral sensitivity, and color discrimination were conducted on a 78-year-old male patient with the condition, who was also interviewed at length about the ways in which his diagnosis affected his daily life. Narrative analysis was employed to identify the relation between his subjective perceptual experiences and functional deficits in identifiable components of the visual system. Psychophysical measurements indicated a complete lack of rod perception and substantially reduced cone sensitivity. Two particular effects of this visual loss emerged during interviews: 1) the development of navigational techniques that relied on light reflections and point sources of light and 2) a reluctance to disclose the extent of visual loss and resulting lifelong psychosocial consequences. This study demonstrates the valuable complementary role that rich descriptive patient testimony can play, in conjunction with laboratory and clinical measurements, in more fully characterizing a disorder and in reaching a more complete understanding of the experience of vision loss. It also evidences the particular suitability of filmmaking techniques as a means of accessing and communicating subjective patient experience