Building blocks of metadata: What can we learn from Lego™?

The idea that metadata, particularly Dublin Core, could be usable as a Lego™-like construction kit has been a popular suggestion for over a decade. In this paper, we first explore what this metaphor originally meant – why the idea is so appealing, and what design lessons we might take from the idea. We take a look at how close we are today to that ideal, looking at examples of real-world metadata design projects, and suggest that at present the situation is often more analogous to a game of Tetris – that is, the construction kit is sometimes limited, time concerns are often an issue, and there is limited opportunity for creativity. We explore patterns of collaboration in existing projects, such as the Scholarly Works Application Profile development. Finally, we ask how what we know about the process of building a shared understanding and formalisation about a domain can help us come closer to the ideal of Dublin Core as an approachable puzzle-game or construction kit

Which lipid measurement should we monitor? An analysis of the LIPID study

OBJECTIVES: To evaluate the optimal lipid to measure in monitoring patients, we assessed three factors that influence the choice of monitoring tests: (1) clinical validity; (2) responsiveness to therapy changes and (3) the size of the long-term ‘signal-to-noise’ ratio. DESIGN: Longitudinal analyses of repeated lipid measurement over 5 years. SETTING: Subsidiary analysis of a Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study—a clinical trial in Australia, New Zealand and Finland. PARTICIPANTS: 9014 patients aged 31–75 years with previous acute coronary syndromes. INTERVENTIONS: Patients were randomly assigned to 40 mg daily pravastatin or placebo. PRIMARY AND SECONDARY OUTCOME MEASURES: We used data on serial lipid measurements—at randomisation, 6 months and 12 months, and then annually to 5 years—of total cholesterol; low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and their ratios; triglycerides; and apolipoproteins A and B and their ratio and their ability to predict coronary events. RESULTS: All the lipid measures were statistically significantly associated with future coronary events, but the associations between each of the three ratio measures (total or LDL cholesterol to HDL cholesterol, and apolipoprotein B to apolipoprotein A1) and the time to a coronary event were better than those for any of the single lipid measures. The two cholesterol ratios also ranked highly for the long-term signal-to-noise ratios. However, LDL cholesterol and non-HDL cholesterol showed the most responsiveness to treatment change. CONCLUSIONS: Lipid monitoring is increasingly common, but current guidelines vary. No single measure was best on all three criteria. Total cholesterol did not rank highly on any single criterion. However, measurements based on cholesterol subfractions—non-HDL cholesterol (total cholesterol minus HDL cholesterol) and the two ratios—appeared superior to total cholesterol or any of the apolipoprotein options. Guidelines should consider using non-HDL cholesterol or a ratio measure for initial treatment decisions and subsequent monitoring

Modelling disease spread in real landscapes: Squirrelpox spread in southern Scotland as a case study

PublishedJournal ArticleThis is the author accepted manuscript. The final version is available from Associazione Teriologica Italiana via the DOI in this record.© 2016 Associazione Teriologica Italiana.There is increasing evidence that invading species can gain an advantage over native species by introducing novel disease. A clear understanding of the role of disease in the expansion of introduced and invading species is therefore essential for the conservation of native species. In this study we focus on the case study system of the UK red and grey squirrel system in which disease-mediated competition has facilitated the replacement of red squirrels by greys. We modify a deterministic model of the squirrel system in which the competition and infection dynamics are well understood to produce a stochastic model which includes a realistic representation of the heterogeneous habitat in Southern Scotland. The model is used to examine the potential spread of infection (squirrelpox virus) through the squirrel system and to examine the impact of conservation measures that control grey squirrel numbers in an attempt to contain disease spread. The results have direct implications for conservation management and we discuss how they have helped shape current and future policy for red squirrel conservation in Scotland. The methods in this study can be readily adapted to represent different systems and since the stochastic population and disease dynamics are underpinned by classical deterministic modelling frameworks the results are applicable in general.AW and PL were supported in part by SNH. AW, MB and PL were supported in part by a NERC Innovations grant NE/M021319/1

A tetravalent alphavirus-vector based dengue vaccine provides effective immunity in an early life mouse model

Dengue viruses (DENV1-4) cause 390 million clinical infections every year, several hundred thousand of which progress to severe hemorrhagic and shock syndromes. Preexisting immunity resulting from a previous DENV infection is the major risk factor for severe dengue during secondary heterologous infections. During primary infections in infants, maternal antibodies pose an analogous risk. At the same time, maternal antibodies are likely to prevent induction of endogenous anti-DENV antibodies in response to current live, attenuated virus (LAV) vaccine candidates. Any effective early life dengue vaccine has to overcome maternal antibody interference (leading to ineffective vaccination) and poor induction of antibody responses (increasing the risk of severe dengue disease upon primary infection). In a previous study, we demonstrated that a non-propagating Venezuelan equine encephalitis virus replicon expression vector (VRP), expressing the ectodomain of DENV E protein (E85), overcomes maternal interference in a BALB/c mouse model. We report here that a single immunization with a tetravalent VRP vaccine induced NAb and T-cell responses to each serotype at a level equivalent to the monovalent vaccine components, suggesting that this vaccine modality can overcome serotype interference. Furthermore, neonatal immunization was durable and could be boosted later in life to further increase NAb and T-cell responses. Although the neonatal immune response was lower in magnitude than responses in adult BALB/c mice, we demonstrate that VRP vaccines generated protective immunity from a lethal challenge after a single neonatal immunization. In summary, VRP vaccines expressing DENV antigens were immunogenic and protective in neonates, and hence are promising candidates for safe and effective vaccination in early life

An Eye-Tracking Methodology for Testing Consumer Preference of Display Trays in a Simulated Retail Environment

Display trays have traditionally been used to support distribution packaging and retail stocking. Yet, it is becoming increasingly common to find display trays as devices to garner attention and increase the shelf presence of packaging. This paper presents a method for testing consumer preference of display trays for liquid dish soap and canned tomatoes in CUShop™, a consumer experience laboratory, using eye-tracking technology. It was hypothesized that display trays would increase total fixation duration and decrease time to first fixation on the respective products tested. However, it was determined that attention to products in a display tray was less favorable to products not in a display tray. Experimental results are limited because of the many variables that exist for display trays. If further studies were to be conducted on a larger variety of display trays using the methodology described, the appeal and attention value of display trays could be comprehensively understood

The Effect of Decorative Foil Stamping on Consumer Attention

Packaging plays a crucial role in communicating product benefits to consumers. Oftentimes, designers use high visibility enhancements to differentiate packaging within the competitive array. Although luxury brands commonly use enhanced graphical and printing techniques to convey high quality products, many private label package designers are also utilizing enhancements to attract attention to their products. This research sought to understand how incorporating foil stamping to the primary panel of fast moving consumer good packaging will affect consumer attention and purchase preference. Through the collection of quantitative data, consumer attention and purchase preference were evaluated. Three different products were selected for evaluation for the study: popcorn, cereal, and boxed pasta dinners. A total of 172 participants completed the study, which took place in a realistic and immersive shopping environment (CUshop™). Two eye tracking metrics were collected using mobile eye tracking technology. Participants completed a qualitative survey, which recorded basic demographic information. Significance tests were conducted to test for statistical differences in consumer attention behavior as well as purchase decision between the foil and control packages. It was determined that foil stamping did significantly (α =0.05) affect consumer attention towards the respective product compared to the control, yet the effect was not consistent. Eye tracking metrics varied across the products and categories tested; some foil stamped samples positively affected consumer attention, others negatively and some had no effect whatsoever. Results show that foil stamping can be a highly strategic influencer (both positively and negatively) on consumer attention and purchase decision. However, it is recommended that this enhancement be tested within an in-context environment to ensure it benefits the brand and product within the competitive array