Consistency Checks for Two-Body Finite-Volume Matrix Elements. II. Perturbative Systems

Using the general formalism presented in [Phys. Rev. D 94, 013008 (2016); Phys. Rev. D 100, 034511 (2019)], we study the finite-volume effects for the 2 þ J → 2 matrix element of an external current coupled to a two-particle state of identical scalars with perturbative interactions. Working in a finite cubic volume with periodicity L, we derive a 1=L expansion of the matrix element through O(1=L5) and find that it is governed by two universal current-dependent parameters, the scalar charge and the threshold two particle form factor. We confirm the result through a numerical study of the general formalism and additionally through an independent perturbative calculation. We further demonstrate a consistency with the Feynman-Hellmann theorem, which can be used to relate the 1=L expansions of the ground-state energy and matrix element. The latter gives a simple insight into why the leading volume corrections to the matrix element have the same scaling as those in the energy, 1=L3, in contradiction to Phys. Rev. D 91, 074509 (2015), which found a 1=L2 contribution to the matrix element. We show here that such a term arises at intermediate stages in the perturbative calculation, but cancels in the final result

Consistency Checks for Two-Body Finite-Volume Matrix Elements: Conserved Currents and Bound States

Recently, a framework has been developed to study form factors of two-hadron states probed by an external current. The method is based on relating finite-volume matrix elements, computed using numerical lattice QCD, to the corresponding infinite-volume observables. As the formalism is complicated, it is important to provide nontrivial checks on the final results and also to explore limiting cases in which more straightforward predictions may be extracted. In this work we provide examples on both fronts. First, we show that, in the case of a conserved vector current, the formalism ensures that the finite-volume matrix element of the conserved charge is volume independent and equal to the total charge of the two-particle state. Second, we study the implications for a two-particle bound state. We demonstrate that the infmite-volume limit reproduces the expected matrix element and derive the leading finite-volume corrections to this result for a scalar current. finally, we provide numerical estimates for the expected size of volume effects in future lattice QCD calculations of the deuteron\u27s scalar charge. We find that these effects completely dominate the infinite-volume result for realistic lattice volumes and that applying the present formalism, to analytically remove an infinite series of leading volume corrections, is crucial to reliably extract the infinite-volume charge of the state

Coral reef species assemblages are associated with ambient soundscapes

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Inter-Research for personal use, not for redistribution. The definitive version was published in Marine Ecology Progress Series 533 (2015): 93-107, doi:10.3354/meps11382.Coral reefs provide a wide array of ecosystem services and harbor some of the highest levels of biodiversity on the planet, but many reefs are in decline worldwide. Tracking changes is necessary for effective resource management. Biological sounds have been suggested as a means to quantify ecosystem health and biodiversity, but this requires an understanding of natural bioacoustic variability and relationships to the taxa present. This investigation sought to characterize spatial and temporal variation in biological sound production within and among reefs that varied in their benthic and fish diversity. Multiple acoustic recorders were deployed for intensive 24-hour periods and longer term (~4-month) duty-cycled deployments on three reefs that varied in coral cover and fish density. Short-term results suggest that while there were statistically significant acoustic differences among recorders on a given reef, these differences were relatively small, indicating that a single sensor may be suitable for acoustic characterization of reefs. Analyses of sounds recorded over ~4 months indicated that the strength of diel trends in a low frequency fish band (100-1000 Hz) was correlated with coral cover and fish density but the strength of high-frequency snapping-shrimp (2-20 kHz) trends was not, suggesting that low-frequency recordings may be better indicators of the species assemblages present. Power spectra varied within reefs over the deployment periods, underscoring the need for long-duration recordings to characterize these trends. These findings suggest that, in spite of considerable spatial and temporal variability within reef soundscapes, diel trends in low-frequency sound production correlate with reef species assemblages.This research was funded by the Mitsubishi Corporation Foundation for the Americas and WHOI’s Access to the Sea program

The British Society for Rheumatology Biologics Registers in Ankylosing Spondylitis (BSRBR-AS) study : Protocol for a prospective cohort study of the long-term safety and quality of life outcomes of biologic treatment

Acknowledgements Oversight of the study is provided by the BSR Registers Committee of which GJM and GTJ are members, together with investigators from BSRBR-RA, representatives from the BSR clinical affairs section and BSR independent members, currently, Alex MacGregor (University of East Anglia), Elaine Dennison (University of Southampton), Jon Packham (Keele University) and patient representatives Ailsa Bosworth and Debbie Cook. We acknowledge the contribution of the International Advisory Group members Desireé van der Heijde (Netherlands), Matthew Brown (Australia) and Walter Maksymowych (Canada). We thank Neil Basu (University of Aberdeen) for his role with regards to pharmacovigilance and the Robertson Centre for Biostatistics (University of Glasgow) for data management services. Author KTM is currently at the Tayside Clinical Trials Unit, University of Dundee. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Peer reviewedPublisher PD

Isospin-breaking corrections to light leptonic decays in lattice QCD+QED at the physical point

We report on the physical-point RBC/UKQCD calculation of the leading isospin-breaking corrections to light-meson leptonic decays. This is highly relevant for future precision tests in the flavour physics sector, in particular the first-row unitarity of the Cabibbo-Kobayashi-Maskawa matrix containing the elements $V_{us}$ and $V_{ud}$. The simulations were performed using Domain-Wall fermions for $2+1$ flavours, and with isospin-breaking effects included perturbatively in the path integral through order $\alpha$ and $(m_u - m_d)/\Lambda _{\mathrm{QCD}}$. We use QED$_{\mathrm{L}}$ for the inclusion of electromagnetism, and discuss here the non-locality of this prescription which has significant impact on the infinite-volume extrapolation.Comment: Proceedings for The 39th International Symposium on Lattice Field Theory, 8th-13th August, 2022, Rheinische Friedrich-Wilhelms-Universit\"at Bonn, Bonn, German

A qualitative study on the acceptability and preference of three types of long-lasting insecticide-treated bed nets in Solomon Islands: implications for malaria elimination

Background. In March 2008, the Solomon Islands and Vanuatu governments raised the goal of their National Malaria Programmes from control to elimination. Vector control measures, such as indoor residual spraying (IRS) and long-lasting insecticidal bed nets (LLINs) are key integral components of this programme. Compliance with these interventions is dependent on their acceptability and on the socio-cultural context of the local population. These factors need to be investigated locally prior to programme implementation. Method. Twelve focus group discussions (FGDs) were carried out in Malaita and Temotu Provinces, Solomon Islands in 2008. These discussions explored user perceptions of acceptability and preference for three brands of long-lasting insecticide-treated bed nets (LLINs) and identified a number of barriers to their proper and consistent use. Results. Mosquito nuisance and perceived threat of malaria were the main determinants of bed net use. Knowledge of malaria and the means to prevent it were not sufficient to guarantee compliance with LLIN use. Factors such as climate, work and evening social activities impact on the use of bed nets, particularly in men. LLIN acceptability plays a varying role in compliance with their use in villages involved in this study. Participants in areas of reported high and year round mosquito nuisance and perceived threat of malaria reported LLIN use regardless of any reported unfavourable characteristics. Those in areas of low or seasonal mosquito nuisance were more likely to describe the unfavourable characteristics of LLINs as reasons for their intermittent or non-compliance. The main criterion for LLIN brand acceptability was effectiveness in preventing mosquito bites and malaria. Discussions highlighted considerable confusion around LLIN care and washing which may be impacting on their effectiveness and reducing their acceptability in Solomon Islands. Conclusion. Providing LLINs that are acceptable will be more important for improving compliance in areas of low or seasonal mosquito nuisance and malaria transmission. The implications of these findings on malaria elimination in Solomon Islands are discussed

A putative relay circuit providing low-threshold mechanoreceptive input to lamina I projection neurons via vertical cells in lamina II of the rat dorsal horn

Background: Lamina I projection neurons respond to painful stimuli, and some are also activated by touch or hair movement. Neuropathic pain resulting from peripheral nerve damage is often associated with tactile allodynia (touch-evoked pain), and this may result from increased responsiveness of lamina I projection neurons to non-noxious mechanical stimuli. It is thought that polysynaptic pathways involving excitatory interneurons can transmit tactile inputs to lamina I projection neurons, but that these are normally suppressed by inhibitory interneurons. Vertical cells in lamina II provide a potential route through which tactile stimuli can activate lamina I projection neurons, since their dendrites extend into the region where tactile afferents terminate, while their axons can innervate the projection cells. The aim of this study was to determine whether vertical cell dendrites were contacted by the central terminals of low-threshold mechanoreceptive primary afferents. Results: We initially demonstrated contacts between dendritic spines of vertical cells that had been recorded in spinal cord slices and axonal boutons containing the vesicular glutamate transporter 1 (VGLUT1), which is expressed by myelinated low-threshold mechanoreceptive afferents. To confirm that the VGLUT1 boutons included primary afferents, we then examined vertical cells recorded in rats that had received injections of cholera toxin B subunit (CTb) into the sciatic nerve. We found that over half of the VGLUT1 boutons contacting the vertical cells were CTb-immunoreactive, indicating that they were of primary afferent origin. Conclusions: These results show that vertical cell dendritic spines are frequently contacted by the central terminals of myelinated low-threshold mechanoreceptive afferents. Since dendritic spines are associated with excitatory synapses, it is likely that most of these contacts were synaptic. Vertical cells in lamina II are therefore a potential route through which tactile afferents can activate lamina I projection neurons, and this pathway could play a role in tactile allodynia

Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Genomic instability can initiate cancer, augment progression, and influence the overall prognosis of the affected patient. Genomic instability arises from many different pathways, such as telomere damage, centrosome amplification, epigenetic modifications, and DNA damage from endogenous and exogenous sources, and can be perpetuating, or limiting, through the induction of mutations or aneuploidy, both enabling and catastrophic. Many cancer treatments induce DNA damage to impair cell division on a global scale but it is accepted that personalized treatments, those that are tailored to the particular patient and type of cancer, must also be developed. In this review, we detail the mechanisms from which genomic instability arises and can lead to cancer, as well as treatments and measures that prevent genomic instability or take advantage of the cellular defects caused by genomic instability. In particular, we identify and discuss five priority targets against genomic instability: (1) prevention of DNA damage; (2) enhancement of DNA repair; (3) targeting deficient DNA repair; (4) impairing centrosome clustering; and, (5) inhibition of telomerase activity. Moreover, we highlight vitamin D and B, selenium, carotenoids, PARP inhibitors, resveratrol, and isothiocyanates as priority approaches against genomic instability. The prioritized target sites and approaches were cross validated to identify potential synergistic effects on a number of important areas of cancer biology

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetic nephropathy. We assessed whether epigenetic modification of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with type 1 diabetes mellitus (T1D). Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease. METHODS: We performed DNA methylation profiling in bisulphite converted DNA from cases and controls using the recently developed Illumina Infinium(R) HumanMethylation27 BeadChip, that enables the direct investigation of 27,578 individual cytosines at CpG loci throughout the genome, which are focused on the promoter regions of 14,495 genes. RESULTS: Singular Value Decomposition (SVD) analysis indicated that significant components of DNA methylation variation correlated with patient age, time to onset of diabetic nephropathy, and sex. Adjusting for confounding factors using multivariate Cox-regression analyses, and with a false discovery rate (FDR) of 0.05, we observed 19 CpG sites that demonstrated correlations with time to development of diabetic nephropathy. Of note, this included one CpG site located 18 bp upstream of the transcription start site of UNC13B, a gene in which the first intronic SNP rs13293564 has recently been reported to be associated with diabetic nephropathy. CONCLUSION: This high throughput platform was able to successfully interrogate the methylation state of individual cytosines and identified 19 prospective CpG sites associated with risk of diabetic nephropathy. These differences in DNA methylation are worthy of further follow-up in replication studies using larger cohorts of diabetic patients with and without nephropathy

The ghost of hosts past: impacts of host extinction on parasite specificity

A growing body of research is focused on the extinction of parasite species in response to host endangerment and declines. Beyond the loss of parasite species richness, host extinction can impact apparent parasite host specificity, as measured by host richness or the phylogenetic distances among hosts. Such impacts on the distribution of parasites across the host phylogeny can have knock-on effects that may reshape the adaptation of both hosts and parasites, ultimately shifting the evolutionary landscape underlying the potential for emergence and the evolution of virulence across hosts. Here, we examine how the reshaping of host phylogenies through extinction may impact the host specificity of parasites, and offer examples from historical extinctions, present-day endangerment, and future projections of biodiversity loss. We suggest that an improved understanding of the impact of host extinction on contemporary host–parasite interactions may shed light on core aspects of disease ecology, including comparative studies of host specificity, virulence evolution in multi-host parasite systems, and future trajectories for host and parasite biodiversity. This article is part of the theme issue ‘Infectious disease macroecology: parasite diversity and dynamics across the globe’