7 research outputs found

    Additional file 2: Figure S1. of Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

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    Changes in gene expression due to CER are also changed in approximately half of the IER participants, but are not clearly correlated with lymphocytes. The heatmap colours show log2 fold change in gene expression of the baseline samples relative to the post-diet samples (green = downregulated, red = upregulated, black = no change). The arrows show subjects predicted to have an energy restriction (orange = CER, blue = IER) or unchanged profiles (grey). Similar results were obtained when considering all probe sets on the array. (XLSX 268 kb

    Additional file 1: Table S1. of Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

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    Dietary intake at baseline and after four to five weeks of IER, during restricted and unrestricted days of IER (n = 23). Table S2. a LCMS+ changes in identified serum metabolites after four to five weeks of IER, on restricted and unrestricted days of IER. b LCMS– changes in identified serum metabolites after four to five weeks of IER on restricted and unrestricted days of IER. c GCMS changes in identified serum metabolites after four to five weeks of IER on restricted and unrestricted days of IER. d GC-MS changes in identified urine metabolites after four to five weeks of IER on restricted and unrestricted days of IER. Table S3 Comparison of baseline characteristics, physical and metabolic changes between the molecular responders and non-responders identified by breast tissue gene expression following IER. Table S4 Percentage change in body weight, BMI, adiposity, lipid and hormone levels with four to five weeks of IER in comparison with four to five weeks of 60 % continuous energy restriction. (PPTX 233 kb
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