2 research outputs found
Cysteine Cathepsin Inhibitors as Anti-Ebola Agents
The recent Ebola virus outbreak in
western Africa highlights the need for novel therapeutics that target
Ebola virus and other filoviruses. Filoviruses require processing
by host cell-derived cysteine cathepsins for productive infection.
Here we report the generation of a focused library of cysteine cathepsin
inhibitors and subsequent screening to identify compounds with potent
activity against viral entry and replication. Our top compounds show
highly potent and broad-spectrum activity against cysteine cathepsins
and were able to effectively block entry of Ebola and Marburg viruses.
These agents are promising leads for development as antifilovirus
therapeutics
Cysteine Cathepsin Inhibitors as Anti-Ebola Agents
The recent Ebola virus outbreak in
western Africa highlights the need for novel therapeutics that target
Ebola virus and other filoviruses. Filoviruses require processing
by host cell-derived cysteine cathepsins for productive infection.
Here we report the generation of a focused library of cysteine cathepsin
inhibitors and subsequent screening to identify compounds with potent
activity against viral entry and replication. Our top compounds show
highly potent and broad-spectrum activity against cysteine cathepsins
and were able to effectively block entry of Ebola and Marburg viruses.
These agents are promising leads for development as antifilovirus
therapeutics