Standard Receiver Operating Characteristic plots.

<p>Plots are displayed for (a) left and (b) right insula using the diagnostic outcome of MDD. These reflect increasing activation with increasing task difficulty. Area under the curve was 0.77 and 0.73 for left and right respectively, see text for further details.</p

Graph of extracted data for insula clusters.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057357#pone-0057357-g002" target="_blank">Figure 2</a> depicts graphs of extracted data for the two cluster of significant difference between the groups in (a) left and (b) right insula cortex.</p

Group difference in bilateral insula cortex.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057357#pone-0057357-g001" target="_blank">Figure 1</a> depicts differences between the healthy controls and HR who developed MDD in the (a) left and (b) right insula cortex. Images are overlaid onto standard brain in MNI space using Mango software package (<a href="http://ric.uthscsa.edu/mango" target="_blank">http://ric.uthscsa.edu/mango</a>). Map represents T-statistic images thresholded equivalent to p = 0.001, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057357#s2" target="_blank">methods</a> for further details (scale T = 3 to 5).</p

Regional brain activation during the intelligence task for males and females (contrast of intelligence judgements versus gender judgements).

<p>SPMs thresholded at P<0.001 for within group contrasts and P<0.005 for between group contrasts.</p

Regional brain activation during the approachability task for males and females for social judgements compared to the baseline rest condition.

<p>SPMs thresholded at P<0.001 for within group contrasts and P<0.005 for between group contrasts.</p

Regional brain activation during the intelligence task for males and females for sex judgements compared to the baseline rest condition.

<p>SPMs thresholded at P<0.001 for within group contrasts and P<0.005 for between group contrasts.</p

Brain activation during approachability judgements in A) males and B) females (SPM thresholded P<0.001).

<p>C) Between group comparison showing greater activation of inferior frontal cortex (IFC) in males than in females during approachability judgements (SPM thresholded P<0.005).</p

Convergent activation changes in the left inferior frontal cortex in males and individuals with ASD.

<p>Red scale indicates regions showing greater activation in males than females. Blue scale indicates regions showing greater activation in participants with ASD than controls. Green scale indicates regions correlating with empathy in males. A) Transverse view, B) Coronal view, C) Saggital view. All contrasts thresholded at T>2.5.</p

Comparison of brain activation during the approachability task between the ASD group and matched male control participants.

<p>SPMs thresholded at P<0.005.</p

Regional brain activation during the approachability task for males and females (contrast of approachability judgements versus gender judgements).

<p>SPMs thresholded at P<0.001 for within group contrasts and P<0.005 for between group contrasts.</p