Non-Gaussianity in Axion N-flation Models

We study perturbations in the multifield axion N-flation model, taking account of the full cosine potential. We find significant differences from previous analyses which made a quadratic approximation to the potential. The tensor-to-scalar ratio and the scalar spectral index move to lower values, which nevertheless provide an acceptable fit to observation. Most significantly, we find that the bispectrum non-Gaussianity parameter fNL may be large, typically of order 10 for moderate values of the axion decay constant, increasing to of order 100 for decay constants slightly smaller than the Planck scale. Such a non-Gaussian fraction is detectable. We argue that this property is generic in multifield models of hilltop inflation

The primordial "f_NL" non-Gaussianity, and perturbations beyond the present horizon

We show a primordial non-linear "f_NL" term may produce unphysically large CMB anisotropy for a red-tilted primordial power spectrum (n<1), because of coupling to primordial fluctuation on the largest scale. We consider a primordial power spectrum models of a running spectral index, and a transition at very low wavenumbers. We find that only negative running spectral index models are allowed, provided that there is no transition at a low wavenumbers (i.e. k -184, at 1 sigma level, on the transition scale of sharp cut-off models, using recent CMB and SDSS data.Comment: v2: Journal information adde

Faxen relations in solids - a generalized approach to particle motion in elasticity and viscoelasticity

A movable inclusion in an elastic material oscillates as a rigid body with six degrees of freedom. Displacement/rotation and force/moment tensors which express the motion of the inclusion in terms of the displacement and force at arbitrary exterior points are introduced. Using reciprocity arguments two general identities are derived relating these tensors. Applications of the identities to spherical particles provide several new results, including simple expressions for the force and moment on the particle due to plane wave excitation.Comment: 11 pages, 4 figure

Impact of Dronedarone Treatment on Healthcare Resource Utilization in Patients with Atrial Fibrillation/Flutter

BACKGROUND: The ATHENA (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter) trial demonstrated a significant reduction (26%) in the rate of first cardiovascular (CV) hospitalization in dronedarone-treated patients with paroxysmal or persistent atrial fibrillation/flutter (AF/AFL). ATHENA was the first trial to demonstrate a CV outcomes benefit, specifically reduced CV hospitalizations, with an antiarrhythmic drug. The objective of this study was to assess the impact of dronedarone treatment on healthcare resource utilization among real-world patients with AF/AFL in United States clinical practice. METHODS: This retrospective cohort study used claims data from the MarketScan(®) databases (Truven Health, Durham, NC, USA) to identify patients with ≥2 concurrent de novo pharmacy claims for dronedarone (≥180 days’ total supply) between June 2009 and March 2011, and with an AF/AFL diagnosis and no heart failure-related hospitalization during the 12 months preceding the initial (index) dronedarone claim. Annualized inpatient and outpatient resource utilization were compared between the pre-index (baseline) and post-index (follow-up) periods. RESULTS: In total, 5,656 AF/AFL patients were prescribed dronedarone for ≥6 months and were followed for mean (standard deviation) 11.9 (4.7) months. Reductions in mean numbers of annualized all-cause, CV- and AF-related hospitalizations (~40–45%), and emergency department visits (~30–45%) were realized. These benefits were offset by increases in office visits (~10–30%) and AF-related prescription claims (74%) after dronedarone initiation. The sub-cohort of patients switching to dronedarone from Prior Rhythm-Control therapy (n = 2,080) showed similar reductions in hospital and emergency department events. CONCLUSIONS: This study suggests that dronedarone use in real-world practice, as in the ATHENA trial, results in substantial reductions in hospital admissions, both in first-line and second-line antiarrhythmic treatment settings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12325-014-0108-x) contains supplementary material, which is available to authorized users

Knowledge of Cardiovascular Medications in a Culturally Diverse Elderly Community: Health Assessment Outcomes by Nursing Students

Lack of knowledge in medication use appears a major hindrance in managing cardiovascular diseases. The cross-sectional study examined the determinants of knowledge of cardiovascular medications in elderly community, using the survey questionnaire and structured interviews to collect data from 99 culturally-diverse elderly people at independent-living facilities in California. Results indicate that the majority of participants was women (82.8%), living alone with an educational level of high-school or higher. Sixty-six participants took at least one cardiovascular medication, and the average number of cardiovascular medications taken was 2.02 (±1.10). The most frequently used cardiovascular medications were lipid-lowering agents and aspirin. Thirtyeight participants demonstrated a lack of knowledge of cardiovascular medication use. After adjusting for age, gender, education, and living status, it was found that having a BMI higher than 25 (OR: 5.46; 95% CI; 1.12, 26.52), drinking alcohol beverages (OR: 0.075; 95% CI: 0.01, 0.83), and having a history of ever-smoking (OR: 54.90; 95% CI: 4.39, 686.29) were statistically significant, independent predictors of a lack of knowledge about cardiovascular medications

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis.

UnlabelledToxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into the nascent parasitophorous vacuole. These GRAs are believed to play key roles in vacuolar remodeling, nutrient uptake, and immune evasion while the parasite is replicating within the host cell. Despite the central role of GRAs in the Toxoplasma life cycle, only a subset of these proteins have been identified, and many of their roles have not been fully elucidated. In this report, we utilize the promiscuous biotin ligase BirA* to biotinylate GRA proteins secreted into the vacuole and then identify those proteins by affinity purification and mass spectrometry. Using GRA-BirA* fusion proteins as bait, we have identified a large number of known and candidate GRAs and verified localization of 13 novel GRA proteins by endogenous gene tagging. We proceeded to functionally characterize three related GRAs from this group (GRA38, GRA39, and GRA40) by gene knockout. While Δgra38 and Δgra40 parasites showed no altered phenotype, disruption of GRA39 results in slow-growing parasites that contain striking lipid deposits in the parasitophorous vacuole, suggesting a role in lipid regulation that is important for parasite growth. In addition, parasites lacking GRA39 showed dramatically reduced virulence and a lower tissue cyst burden in vivo Together, the findings from this work reveal a partial vacuolar proteome of T. gondii and identify a novel GRA that plays a key role in parasite replication and pathogenesis.ImportanceMost intracellular pathogens reside inside a membrane-bound vacuole within their host cell that is extensively modified by the pathogen to optimize intracellular growth and avoid host defenses. In Toxoplasma, this vacuole is modified by a host of secretory GRA proteins, many of which remain unidentified. Here we demonstrate that in vivo biotinylation of proximal and interacting proteins using the promiscuous biotin ligase BirA* is a powerful approach to rapidly identify vacuolar GRA proteins. We further demonstrate that one factor identified by this approach, GRA39, plays an important role in the ability of the parasite to replicate within its host cell and cause disease

An Accounting Program Merit Pay Survey

Basing the compensation of accounting professors on merit pay in order to encourage better teaching, research and service is controversial. Before the effectiveness of merit-based salary plans can be examined empirically, it must be determined which accounting programs use such a system. In this study, the 852 accounting programs in the United States were surveyed to identify the methods in use to adjust the salaries of individual professors. Initial findings indicate that schools using a merit system usually do not also offer time in grade increases and that doctoral granting schools and AACSB accredited schools are more likely to use a merit system. &nbsp

Recognition of micro-array protein crystals images using multi-scale representations

Micro-array protein crystal images are now routinely acquired automatically by CCD cameras. High-throughput automatic classification of protein crystals requires to alleviation of the time-consuming task of manual visual inspection. We propose a classification framework combined with a multi-scale image processing method for recognizing protein crystals and precipitates versus clear drops. The main two points of the processing method are the multi-scale Laplacian pyramid filters and histogram analysis techniques to find an effective feature vector. The processing steps include: 1. Tray well cropping using Radon Transform; 2. Droplet cropping using an ellipsoid Hough Transform; 3. Multi-scale image separation with Laplacian pyramidal filters; 4. Feature vector extraction from the histogram of the multi-scale boundary images. The feature vector combines geometric and texture features of each image and provides input to a feed forward binomial neural network classifier. Using human (expert crystallographers) classified images as ground truth, the current experimental results gave 86% true positive and 94% true negative rates (average true percentage is 90%) using an image database which contained over 2,000 images. To enable NESG collaborators to carry our crystal classification, a web-based Matlab server was also developed. Users at other locations on the internet can input micro-array crystal image folders and parameters for training and testing processes through a friendly web interface. Recognition results are shown on the client side website and may be downloaded by a remote user as an Excel spreadsheet file