Low-Energy Dynamics of String Solitons

The dynamics of a class of fivebrane string solitons is considered in the moduli space approximation. The metric on moduli space is found to be flat. This implies that at low energies the solitons do not interact, and their scattering is trivial. The range of validity of the approximation is also briefly discussed.Comment: 8 pages, Minor typos correcte

Critical Theories of the Dissipative Hofstadter Model

It has recently been shown that the dissipative Hofstadter model (dissipative quantum mechanics of an electron subject to uniform magnetic field and periodic potential in two dimensions) exhibits critical behavior on a network of lines in the dissipation/magnetic field plane. Apart from their obvious condensed matter interest, the corresponding critical theories represent non-trivial solutions of open string field theory, and a detailed account of their properties would be interesting from several points of view. A subject of particular interest is the dependence of physical quantities on the magnetic field since it, much like $\theta_{\rm QCD}$, serves only to give relative phases to different sectors of the partition sum. In this paper we report the results of an initial investigation of the free energy, $N$-point functions and boundary state of this type of critical theory. Although our primary goal is the study of the magnetic field dependence of these quantities, we will present some new results which bear on the zero magnetic field case as well.Comment: 42 pages (25 reduced

HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E–restricted CD8+ T cell responses in convalescent patients with coronavirus disease 2019. These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia–restricted anti–SARS-CoV-2 CD8+ T cells. HLA-E peptide–specific CD8+ T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. Thus, HLA-E–restricted T cells could contribute to the control of SARS-CoV-2 infection alongside classical T cells

HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E-restricted CD8+ T cell responses in convalescent patients with coronavirus disease 2019. These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia-restricted anti-SARS-CoV-2 CD8+ T cells. HLA-E peptide-specific CD8+ T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. Thus, HLA-E-restricted T cells could contribute to the control of SARS-CoV-2 infection alongside classical T cells