DTI Histogram Group Results.

<p>Std. Deviation–Standard Deviation; Peak Location–mode of the histogram; Peak Height–normalised frequency of the mode. Test results in bold are significant at p<0.05 level (uncorrected).</p

MRI results in SVD cases and controls.

<p><i>Values: Mean (Standard Deviation). Quartile descriptives: Minimum, lower quartile, median, upper quartile, maximum; NBV–Normalised Brain Volume, WMH–White Matter Hyperintensity.CMB–Cerebral Microbleed.</i></p

Demographics of SVD and control groups.

<p><i>BP–Blood Pressure; DM–Diabetes Mellitus; BMI–Body Mass Index. All values are Mean (SD) or proportion (%) as specified. Independent sample t-test or Chi-squared analysis used as appropriate.</i></p

Cognitive Profile in the SVD Group.

<p>Average scores for cognitive indices are presented for the SVD group. Error Bars represent +/−1 standard error of the mean. Solid line at zero represents the expected performance for a group of average ability. EF–Executive Function; PS–Processing Speed; WM–Working Memory; LTM–Long-term “episodic” memory; PIQ–Performance IQ; VIQ–Verbal IQ; GC–Global Cognition measure. ***index score significantly different from zero, p<0.001; *index score significantly different from zero, p<0.05.</p

Predictors of key cognitive domains in SVD.

<p><i>Values show Standardised regression coefficients: β (p-value) for predictor variables in regression models of: EF-Executive Function, and PS–Processing Speed.</i></p>1<p><i>Single variable models control for effects of age, gender and NART-IQ. Values in Bold remain significant after multiple comparisons correction (Holm-Bonferroni).</i></p>2<p><i>Multiple variable models include all the terms indicated as well as age, gender and NART-IQ. A subset of variables were included in the multi-predictor models, as described in the statistical analysis part of the methods section. Models were highly significant: EF: R² = 0.60; F_(8,105) = 19.8, p<0.0001; PS: R² = 0.49; F_(8,105) = 12.8, p<0.0001. Significant terms in each model are highlighted in bold.</i></p

Correlation between the number of infratentorial, deep, and lobar cerebral microbleeds and drugs, clinical and other neuroimaging features in 125 CADASIL patients.

<p>Correlation between the number of infratentorial, deep, and lobar cerebral microbleeds and drugs, clinical and other neuroimaging features in 125 CADASIL patients.</p

Examples of different locations of cerebral microbleeds in our sample of CADASIL patients.

<p>T2*-weighted magnetic resonance images showing cerebral microbleeds (white arrows) in infratentorial (A), deep subcortical (B, C) and lobar locations (D).</p

Demographic, clinical and neuroimaging characteristics of the 125 CADASIL patients enrolled in the study.

<p>Demographic, clinical and neuroimaging characteristics of the 125 CADASIL patients enrolled in the study.</p

Correlation between the total number of cerebral microbleeds and demographics, drugs, clinical and other neuroimaging features in 125 CADASIL patients.

<p>Correlation between the total number of cerebral microbleeds and demographics, drugs, clinical and other neuroimaging features in 125 CADASIL patients.</p

Total number of cerebral microbleeds in 125 CADASIL patients.

<p>Proportions of patients with different numbers of CMB are reported in the bar graph and in the table.</p