Additional file 3: of The effects of HIV self-testing on the uptake of HIV testing and linkage to antiretroviral treatment among adults in Africa: a systematic review protocol

DATA EXTRACTION FORM. (DOCX 115 kb

Cumulative hazard estimate for virological failure.

<p>Cumulative hazard estimate for virological failure.</p

Associations between baseline characteristics and time to virological failure.

<p>*per category; EFV, efavirenz; NVP, nevirapine.</p><p>schoenfelds p = 0.12.</p

Comparison of prior and posterior distributions.

<p>Comparison of prior and posterior distributions.</p

Age and sex differences in mortality levels (1 July 2005–30 June 2006).

<p>HIV and non-HIV deaths by 5-year age group in (a) females and (b) males. Bars represent posterior means from the main analysis. Error bars represent 95% confidence intervals around model estimates of total deaths (HIV and non-HIV combined).</p

Smoothed hazard of loss to follow-up before and after ascertainment of vital status.

<p>Smoothed hazard estimates for loss to follow-up (LTF) before (A) and after (B) correction for mortality. Before ascertainment of vital status the hazard of LTF decreased over time on ART; after correcting LTF for mortality, the hazard of true LTF increased with time on ART.</p

Patient characteristics at initiation of ART.

<p>ART, antiretroviral treatment; LTF, Lost to follow-up; IQR, interquartile range; PMTCT, prevention of mother to child transmission; TB, tuberculosis; AZT, zidovudine; 3TC, lamivudine; NVP, nevirapine; D4T, stavudine; EFV, efavirenz. </p><p>* All patients not lost to follow-up, including deaths occurring within 3 months after loss to follow-up;</p><p>** Patients lost to follow-up with available civil identification number who were alive 3 months after being lost.</p

Cumulative probability of true LTF by year of initiation on ART.

<p>Weighted Kaplan-Meier estimates of true LTF by year of initiation on ART. True LTF increased and occurred earlier with each calendar year, as enrolment on ART increased.</p

Cumulative probability of LTF before and after correction for mortality.

<p>Kaplan-Meier estimates of cumulative probability of loss to follow-up (LTF) before and after correction for mortality by ascertainment of vital status of patients lost to follow-up through the national vital registration system. Routine monitoring overestimated LTF by 4% at 5 years on ART (23.9 vs. 19.7%).</p

Trends in modelled and recorded deaths in adults (ages 20–59 years).

<p>Modelled and recorded HIV deaths in (a) females and (b) males for the years 1990–2014. Shaded areas represent posterior means from the main analysis, and dashed lines represent model estimates from the ‘no ART’ counterfactual. Dots represent recorded death estimates, after adjustment for incomplete vital registration.</p